NK Cells in Cancer: Mechanisms of Dysfunction and Therapeutic Potential

被引:22
|
作者
Portale, Federica [1 ]
Di Mitri, Diletta [1 ,2 ]
机构
[1] IRCCS Humanitas Res Hosp, Tumor Microenvirom Unit, I-20089 Milan, Italy
[2] Humanitas Univ, Dept Biomed Sci, I-20072 Milan, Italy
关键词
NK cells; tumor microenvironment; immunotherapy; NATURAL-KILLER-CELLS; REGULATORY T-CELLS; MHC CLASS-I; DENDRITIC CELLS; CROSS-TALK; PATROLLING MONOCYTES; TUMOR-METASTASIS; TARGET-CELLS; ANTITUMOR; RECEPTOR;
D O I
10.3390/ijms24119521
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Natural killer cells (NK) are innate lymphocytes endowed with the ability to recognize and kill cancer cells. Consequently, adoptive transfer of autologous or allogeneic NK cells represents a novel opportunity in cancer treatment that is currently under clinical investigation. However, cancer renders NK cells dysfunctional, thus restraining the efficacy of cell therapies. Importantly, extensive effort has been employed to investigate the mechanisms that restrain NK cell anti-tumor function, and the results have offered forthcoming solutions to improve the efficiency of NK cell-based therapies. The present review will introduce the origin and features of NK cells, summarize the mechanisms of action and causes of dysfunction of NK cells in cancer, and frame NK cells in the tumoral microenvironment and in the context of immunotherapies. Finally, we will discuss therapeutic potential and current limitations of NK cell adoptive transfer in tumors.
引用
收藏
页数:22
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