Generation of an induced pluripotent stem cell line (ITXi012-A) from a patient with genetically determined high-lipoprotein(a) plasma levels

被引：1
|
作者：
Caillaud, Amandine [1 ]
Bray, Lise [1 ]
Girardeau, Aurore [1 ]
Begue-Racape, Zoe [1 ]
Vince, Lucie [1 ]
Patitucci, Murielle [1 ]
Le May, Cedric [1 ]
Lambert, Gilles [2 ]
Cariou, Bertrand [1 ]
Rimbert, Antoine [1 ]
机构：
[1] Univ Nantes, Inst Thorax, CHU Nantes, CNRS,INSERM, F-44000 Nantes, France
[2] Univ La Reun, Inserm UMR DeTROI 1188, St Denis De La Reunion, France
来源：
STEM CELL RESEARCH | 2023年 / 72卷
关键词：
Unique stem cell line identifier ITXi012-A; Additional origin info required for; human ESC or iPSC; Episomal iPSC reprogramming kit; Genetic Modification No; Evidence of the reprogramming; transgene loss (including genomic; copy if applicable);
D O I：
10.1016/j.scr.2023.103205
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Elevated circulating lipoprotein(a) (Lp(a)) is a genetically determined risk factor for coronary artery disease and aortic valve stenosis (Tsimikas, 2017). Importantly, the LPA gene, which encodes the apolipoprotein(a) (protein-component of Lp(a)), is missing in most species, and human liver cell-lines do not secrete Lp(a). There is a need for the development of human in vitro models suitable for investigating biological mechanisms involved in Lp(a) metabolism. We here generated and characterized iPSCs from a patient with extremely high Lp(a) plasma levels genetically determined (Coassin et al., 2022). This unique cellular model offers great opportunities and new perspectives for investigations on biological mechanisms involved in Lp(a) metabolism.
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页数：5
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