FGFR2 genetic variants in women with breast cancer

被引：0

作者：

Dix-Peek, Therese ^{[1
]}

Dickens, Caroline ^{[1
]}

Augustine, Tanya N. ^{[2
]}

Phakathi, Boitumelo P. ^{[3
]}

van den Berg, Eunice J. ^{[4
,5
]}

Joffe, Maureen ^{[6
,7
,8
]}

Ayeni, Oluwatosin A. ^{[6
,7
,8
,9
]}

Cubasch, Herbert ^{[7
,8
,10
,11
]}

Nietz, Sarah ^{[7
,11
]}

Mathew, Christopher G. ^{[12
,13
,14
,15
]}

Hayat, Mahtaab ^{[12
,14
,15
]}

Neugut, Alfred I. ^{[16
,17
]}

Jacobson, Judith S. ^{[16
,17
]}

Ruff, Paul ^{[1
,7
,8
]}

Duarte, Raquel A. B. ^{[1
]}

机构：

[1] Univ Witwatersrand, Fac Hlth Sci, Sch Clin Med, Dept Internal Med, 7 York Rd, ZA-2193 Johannesburg, South Africa

[2] Univ Witwatersrand, Fac Hlth Sci, Sch Anat Sci, ZA-2193 Johannesburg, South Africa

[3] Univ KwaZulu Natal, Fac Hlth Sci, Sch Clin Med, Dept Surg, ZA-4001 Durban, South Africa

[4] Chris Hani Baragwanath Hosp, Dept Histopathol, Natl Hlth Lab Serv, ZA-1864 Johannesburg, South Africa

[5] Univ Witwatersrand, Fac Hlth Sci, Dept Anat Pathol, ZA-2193 Johannesburg, South Africa

[6] Univ Witwatersrand, Fac Hlth Sci, Strengthening Oncol Serv Res Unit, ZA-2193 Johannesburg, South Africa

[7] Univ Witwatersrand, Fac Hlth Sci, South African Med Res Council, Common Epithelial Canc Res Ctr, ZA-2193 Johannesburg, South Africa

[8] Univ Witwatersrand, Fac Hlth Sci, Noncommunicable Dis Res Div, Wits Hlth Consortium PTY Ltd, ZA-2193 Johannesburg, South Africa

[9] Univ Witwatersrand, Fac Hlth Sci, Dept Radiat Sci, Div Radiat Oncol, ZA-2193 Johannesburg, South Africa

[10] Chris Hani Baragwanath Acad Hosp, Batho Pele Breast Unit, ZA-1860 Soweto, South Africa

[11] Univ Witwatersrand, Fac Hlth Sci, Dept Surg, ZA-2193 Johannesburg, South Africa

[12] Univ Witwatersrand, Sydney Brenner Inst Mol Biosci, Fac Hlth Sci, ZA-2193 Johannesburg, South Africa

[13] Kings Coll London, Fac Life Sci & Med, Dept Med & Mol Genet, London WC2R 2LS, England

[14] Univ Witwatersrand, Fac Hlth Sci, Natl Hlth Lab Serv, ZA-2193 Johannesburg, South Africa

[15] Univ Witwatersrand, Fac Hlth Sci, Sch Pathol, ZA-2193 Johannesburg, South Africa

[16] Vagelos Coll Phys & Surg, Herbert Irving Comprehens Canc Ctr, New York, NY 10032 USA

[17] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10032 USA

来源：

MOLECULAR MEDICINE REPORTS | 2023年 / 28卷 / 06期

关键词：

FGFR2; SNP; African; breast cancer; heterogenous; risk; GENOME-WIDE ASSOCIATION; AFRICAN-AMERICAN; SUSCEPTIBILITY; RISK; REGULATOR; DIVERSITY; MIGRATION; ANCESTRY; SUBTYPES; THERAPY;

D O I：

10.3892/mmr.2023.13113

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Black African populations are more genetically diverse than others, but genetic variants have been studied primarily in European populations. The present study examined the association of four single nucleotide polymorphisms (SNPs) of the fibroblast growth factor receptor 2, associated with breast cancer in non-African populations, with breast cancer in Black, southern African women. Genomic DNA was extracted from whole blood samples of 1,001 patients with breast cancer and 1,006 controls (without breast cancer), and the rs2981582, rs35054928, rs2981578, and rs11200014 polymorphisms were analyzed using allele-specific Kompetitive allele-specific PCR (TM), and the chi 2 or Fisher's exact tests were used to compare the genotype frequencies. There was no association between those SNPs and breast cancer in the studied cohort, although an association was identified between the C/C homozygote genotype for rs2981578 and invasive lobular carcinoma. These results show that genetic biomarkers of breast cancer risk in European populations are not necessarily associated with risk in sub-Saharan African populations. African populations are more heterogenous than other populations, and the information from this population can help focus genetic risks of cancer in this understudied population.

引用

页数：12

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