IMMUNOHISTOCHEMICAL ANALYSIS BY KI67 AND IDH1 IN PATIENTS WITH CHONDROSARCOMA

被引：1
|
作者：
Ribeiro, Marcelo Barbosa [1 ,2 ,3 ]
Ibiapina, Jerusia Oliveira [3 ]
Baptista, Andre Mathias [4 ]
de Camargo, Olavo Pires [4 ]
机构：
[1] Univ Fed Piaui, Teresina, PI, Brazil
[2] Ctr Univ Unifacid, Teresina, PI, Brazil
[3] Assoc Piauiense Combate Canc Alcenor Almeida, Teresina, PI, Brazil
[4] Univ Sao Paulo, Inst Ortoped & Traumatol IOT HCFMUSP, Hosp Clin, Fac Med, Sao Paulo, SP, Brazil
来源：
ACTA ORTOPEDICA BRASILEIRA | 2023年 / 31卷 / 03期
关键词：
Chondrosarcoma; Immunohistochemistry; Prognosis; EXPRESSION; MUTATIONS; SURVIVAL; KI-67; BONE;
D O I：
10.1590/1413-785220233103e267212
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
Objective: To perform an immunohistochemical evaluation using the IDH1 and Ki67 markers in patients who underwent treatment for chondrosarcoma in a reference service center in Brazil. Methods: Retrospective analytical observational study using medical records of patients diagnosed with chondrosarcoma. Besides the epidemiological and clinical profile, important variables for prognosis and correlation with immunohistochemical analysis results with Ki67 and IDH1 markers were evaluated. Results: Histopathological examinations by immunohistochemistry of 56 patients were analyzed, 52% of which were women, with the age group 20-60 years being more prevalent. Grade 1 and 2 histological subtypes corresponded to most chondrosarcomas. The femur, humerus, and tibia were the most frequent anatomical sites. Most tumors (59%) were larger than 8 cm. Ki67 expression was very low (< 10%) in 98% of patients. The analysis of IDH1 was positive in 43% of the cases. The correlation between IDH1 positivity and tumor size was statistically significant, but regarding survival, we observed no significance. Conclusion: Immunohistochemical analysis using IDH1 and Ki67 markers in patients with conventional chondrosarcoma is not useful for prognostic guidance.
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页数：4
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