Intestinal flora in the constipation patients before versus after lactulose intervention

被引：6

作者：

Ma, Jianxia ^{[1
]}

Ma, Houlian ^{[1
]}

Zheng, Songbai ^{[1
]}

Yu, Xiaofeng ^{[1
]}

Wang, Ke ^{[1
]}

Wang, Jun ^{[1
]}

Pan, Yiru ^{[2
]}

Yao, Jianfeng ^{[1
]}

机构：

[1] Fu Dan Univ, Hua Dong Hosp, Dept Gastroenterol, Shanghai 200040, Peoples R China

[2] Fu Dan Univ, Hua Dong Hosp, Clin Lab, Shanghai, Peoples R China

来源：

MEDICINE | 2023年 / 102卷 / 32期

关键词：

chronic functional constipation; gene sequencing; intestinal flora; lactulose; FUNCTIONAL CONSTIPATION; METHANE PRODUCTION; FECAL MICROBIOTA; LAXATIVE USE; EPIDEMIOLOGY; PATTERNS; MUCOSA; ADULTS;

D O I：

10.1097/MD.0000000000034703

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This study aimed to investigate the characteristics of intestinal flora in patients with chronic functional constipation before and after lactulose intervention. Twenty-nine patients with constipation in the treatment group received oral lactulose (15 mL/d) for a month. Twenty healthy subjects served as controls. Stool specimens were collected before and after lactulose treatment. Fecal bacteria were examined by 16SrRNA gene sequencing and bioinformatics analysis. After lactulose treatment, most bacteria in the constipation group, including Bifidobacteria, Bacillus cereus, Prevotella, Bacillus, Anaerostipes, Oribacterium, and Mogibacterium increased as compared to those in the healthy control group. Anaerotruncus declined in the healthy control group after lactulose treatment. Our study shows lactulose can increase the abundance of probiotics, optimize the intestinal microenvironment, and alleviate constipation.

引用

页数：8

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