A novel CO2-sensitive in situ deep eutectic solvent system: Efficient extraction of polyphenol phytochemicals

In the present study, monoethanolamine (MEA) was applied as a solvent for the extraction of polyphenols from lingonberry (Vaccinium vitis-idaea L.) pomace. In addition to solvent extraction an in situ DES could be formed with the secondary metabolites to obtain higher extraction yield. FT-IR, DSC, and TGA were used to validate MEA-based in situ DESs with reference compound. And the reusability of the solvent system still reached about 70.2% after the fifth cycles. The Box-Behnken experimental design method was used to de-termine the extraction efficiency under optimal conditions in practical applications, and the highest extraction yields of polyphenols increased 1.06-1.21 folds higher than that of traditional solvents. In addition, the extraction mechanism was studied using density functional theory. In summary, this study proposed a green and sustainable strategy to replace traditional solvents for targeted extraction of polyphenols from plants.(c) 2023 Published by Elsevier Ltd on behalf of Institution of Chemical Engineers.