The synthesis of 2H-pyrido[3,4-c][1,2]benzoxazine-2,4(3H)-diones from 6-oxo-6H-1,2-oxazine-3-carboxylates

被引：1

作者：

Ivanov, Dmitry S. ^{[1
]}

Zaitseva, Elvira R. ^{[1
]}

Smirnov, Alexander Yu. ^{[1
,2
]}

Nizovtsev, Alexey V. ^{[1
]}

Baleeva, Nadezhda S. ^{[1
,2
]}

Baranov, Mikhail S. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, 16-10 Miklukho Maklaya St, Moscow 117997, Russia

[2] Pirogov Russian Natl Res Med Univ, 1 Ostrovityanova St, Moscow 117997, Russia

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2023年 / 59卷 / 1-2期

基金：

俄罗斯科学基金会;

关键词：

imides; nitroacetic esters; oxazinones; condensation; 4H-1,2-BENZOXAZINES; OXIDATION;

D O I：

10.1007/s10593-023-03168-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple procedure was developed for the synthesis of 2H-pyrido[3,4-c][1,2]benzoxazine-2,4(3H)-diones by the treatment of o-fluorophenyl-substituted 6-oxo-6H-1,2-oxazine-3-carboxylates with primary amines. The reaction proceeded according to the mechanism previously described for the formation of 3-(hydroxyimino)pyridine-2,6-diones followed by intramolecular nucleophilic substitution involving the hydroxyimino group to form the 1,2-oxazine ring.

引用

页码：101 / 104

页数：4

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