Transformation of remote toehold-mediated strand displacement for expanding the regulatory toolbox

被引：1

作者：

Hu, Minghao ^{[1
]}

Chu, Ziyi ^{[1
]}

Wang, Haitao ^{[2
]}

Zhao, Wenbo ^{[2
]}

Wu, Tongbo ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Wuhan 430030, Peoples R China

[2] State Key Lab NBC Protect Civilian, Beijing 102205, Peoples R China

来源：

MICROCHEMICAL JOURNAL | 2023年 / 190卷

基金：

中国国家自然科学基金;

关键词：

Remote toehold; Strand displacement; Toehold exchange; Nucleic acids;

D O I：

10.1016/j.microc.2023.108706

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Strand replacement faces complex and diverse application scenarios as a "cog" in the DNA machine and the DNA network. Existing strand displacement tools can be developed with new capabilities different from initial demonstrations. We have modified remote toehold-mediated strand displacement with the ability to operate under asymmetric spacer and asymmetric responses to spacer hybridization. Additionally, we have uncovered a series of unique modulations. These secondary excavations will expand the application of the strand displacement toolbox.

引用

页数：6

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