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CD36 as a double-edged sword in cancer
被引:6
|作者:
Jiang, Muwei
[1
]
Karsenberg, Renske
[1
]
Bianchi, Frans
[1
]
Bogaart, Geert van den
[1
]
机构:
[1] Univ Groningen, Groningen Biomol Sci & Biotechnol Inst, Dept Mol Immunol, Nijenborgh 7, Groningen, Netherlands
基金:
欧洲研究理事会;
关键词:
CD36;
Cancer;
oxLDL;
Lipid metabolism;
Tumor immunology;
LOW-DENSITY-LIPOPROTEIN;
FATTY-ACID UPTAKE;
PANCREATIC ADENOCARCINOMA;
TUMOR MICROENVIRONMENT;
METABOLIC ADAPTATION;
BINDING-SITE;
RECEPTOR;
CELLS;
DEFICIENCY;
ACTIVATION;
D O I:
10.1016/j.imlet.2023.12.002
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
The membrane protein CD36 is a lipid transporter, scavenger receptor, and receptor for the antiangiogenic protein thrombospondin 1 (TSP1). CD36 is expressed by cancer cells and by many associated cells including various cancer-infiltrating immune cell types. Thereby, CD36 plays critical roles in cancer, and it has been reported to affect cancer growth, metastasis, angiogenesis, and drug resistance. However, these roles are partly contradictory, as CD36 has been both reported to promote and inhibit cancer progression. Moreover, the mechanisms are also partly contradictory, because CD36 has been shown to exert opposite cellular effects such as cell division, senescence and cell death. This review provides an overview of the diverse effects of CD36 on tumor progression, aiming to shed light on its diverse pro- and anti-cancer roles, and the implications for therapeutic targeting.
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页码:7 / 15
页数:9
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