Functioning of P-Glycoprotein during Pregnancy in Rabbits

被引：1
|
作者：
Popova, N. M. [1 ]
Shchulkin, A. V. [1 ]
Chernykh, I. V. [1 ]
Mylnikov, P. Yu. [1 ]
Yakusheva, E. N. [1 ]
机构：
[1] Ryazan State Med Univ, Minist Hlth Russian Federat, Ryazan, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2023年 / 174卷 / 04期
关键词：
P-glycoprotein (Pgp; ABCB1-protein); protein content; protein activity; fexofenadine; EXPRESSION; PLACENTA;
D O I：
10.1007/s10517-023-05723-3
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The level P-glycoprotein (Pgp) in organs of pregnant rabbits and its content and activity in the placental barrier at different stages of pregnancy were studied. An increase in Pgp content in the jejunum on days 7, 14, 21, and 28 of pregnancy in comparison with this parameter non-pregnant females was revealed by ELISA; in the liver, Pgp content was higher on day 7 and tended to increase on day 14; in the kidney and cerebral cortex, Pgp content was higher on day 28 of pregnancy in parallel with an increase in serum progesterone concentration. We also observed a decrease in Pgp content in the placenta on days 21 and 28 of pregnancy in comparison with day 14 and a decrease in Pgp activity in the placental barrier, which was confirmed by enhanced penetration of fexofenadine (Pgp substrate) through the barrier.
引用
收藏
页码：431 / 434
页数：4
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