Experimental Study of Antidepressant Properties of Afobazole

被引：0
|
作者：
Kapitsa, I. G. [1 ]
Alymov, A. A. [1 ]
Savinkova, E. V. [1 ]
Voronina, T. A. [1 ]
Seredenin, S. B. [1 ]
机构：
[1] VV Zakusov Res Inst Pharmacol, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2023年 / 175卷 / 1期
关键词：
depressive-like behavior; & sigma; 1; receptors; Afobazole; BD-1047; C57BL; 6; mice; BDNF;
D O I：
10.1007/s10517-023-05811-4
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the effects of oral administration of Afobazole in a dose of 10 mg/kg for 5 days on depressive-like behavior of male C57BL/6 mice in the tail suspension test in comparison with amitriptyline (10 mg/kg) or fluoxetine (20 mg/kg) treatment. Afobazole produced an antidepressant effect similar to amitriptyline, but inferior to fluoxetine. The s1 receptor antagonist BD-1047 in a dose of 5 mg/kg blocked the antidepressant effect of Afobazole, which indicates the involvement of s1 receptors in the antidepressant effect of the drug.
引用
收藏
页码：59 / 62
页数：4
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