neo-Clerodane and tiliifolane-type diterpenoids, and other constituents from Salvia pennellii

被引：2
|
作者：
Sepulveda-Cuellar, Laura [1 ,2 ]
Cardenas, Jorge [3 ]
Toscano, Ruben A. [3 ]
Rivera-Chavez, Jose [3 ]
Bautista, Elihu [1 ]
Bedolla-Garcia, Brenda Y. [4 ]
Flores, Joel [2 ]
机构：
[1] CONACYT, Inst Potosino Invest Cient & Tecnol AC, Div Biol Mol, San Luis Potosi, Mexico
[2] Inst Potosino Invest Cient & Tecnol AC, Div Ciencias Ambientales, San Luis Potosi, Mexico
[3] Univ Nacl Autonoma Mexico, Inst Quim, Mexico City, DF, Mexico
[4] Ctr Reg Bajio, Inst Ecol AC, Patzcuaro, Michoacan, Mexico
来源：
TETRAHEDRON LETTERS | 2023年 / 122卷
关键词：
Terpenoids; Structural elucidation; Biological prospecting; Mexican flora; Salvia species; UNPRECEDENTED SKELETON; MULTIDRUG-RESISTANCE; LAMIACEAE;
D O I：
10.1016/j.tetlet.2023.154491
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Two undescribed neo-clerodanes (1 and 2) and a novel tiliifolane (3) diterpenoids, were isolated from the leaves and flowers of Salvia pennellii. Wirikutin (1) and 15-epi-wirikutin (2) were isolated as a C-15 epi -meric mixture containing a 5-hydroxyfuran-2(5H)-one moiety in the side chain of the neo-clerodane framework. Wixarikolide (3) was isolated as a D3(20) derivative of tiliifodiolide. The structures of com-pounds 1/2 were deduced through the analyses of their MS spectrometric, and the 1D/2D NMR data. The structure of 3 was determined directly by single crystal X-ray diffraction. The PTP1B inhibitory activ-ity of compounds 1/2 was assayed.(c) 2023 Elsevier Ltd. All rights reserved.
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页数：4
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