Phytoconstituents from Turraea obtusifolia and their antiplasmodial activity

被引：1

作者：

Mianda, Sephora Mutombo ^{[1
]}

Moyo, Phanankosi ^{[1
,2
]}

Maboane, Suzan ^{[2
]}

Birkholtz, Lyn-Marie ^{[2
]}

Maharaj, Vinesh J. ^{[1
]}

机构：

[1] Univ Pretoria, Fac Nat & Agr Sci, Dept Chem, Pretoria, South Africa

[2] Univ Pretoria, Inst Sustainable Malaria Control, Dept Biochem Genet & Microbiol, Pretoria, South Africa

来源：

NATURAL PRODUCT RESEARCH | 2024年 / 38卷 / 20期

关键词：

Turraea obtusifolia; steroids; limonoids; plasmodium falciparum; ARTEMISININ RESISTANCE; PLASMODIUM-FALCIPARUM; PREGNANE STEROIDS; MEDICINAL-PLANTS; LIMONOIDS; MELIACEAE; BIOSYNTHESIS; CONSTITUENTS; TOXICITY; EXTRACTS;

D O I：

10.1080/14786419.2023.2255921

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Three new steroids, turranin M, N and O (1-3), together with four known limonoids, nymania 1 (4), rubralin B (5), aphapolynin C (6) and Trichillia substance Tr B (7), were isolated from the leaves of Turraea obtusifolia. Their chemical structures were elucidated using NMR and MS. Rubralin B (5) displayed good activity against the asexual parasites from the drug sensitive Plasmodium falciparum NF54 strain with an IC50 value of 3.47 mu g/mL (4.57 mu M), nymania 1 (4) showed a weak activity (IC50 13.36 mu g/mL (19.40 mu M)) and the rest of compounds had IC50 > 20 mu g/mL. [GRAPHICS] .

引用

页码：3542 / 3554

页数：13

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