Red Blood Cell Vitamin C Concentration and Its Effect on Deformability in Pediatric Sickle Cell Disease

被引：0

作者：

Choi, Daniel H. ^{[1
,3
,5
]}

Violet, Pierre-Christian ^{[4
]}

Majumdar, Suvankar ^{[2
]}

Levine, Mark ^{[4
]}

机构：

[1] Childrens Natl Hosp, George Washington Sch Med & Hlth Sci, Dept Pediat, Div Crit Care Med, Washington, DC USA

[2] George Washington Univ, Childrens Natl Hosp, Dept Pediat, Div Hematol,Sch Med & Hlth Sci, Washington, DC USA

[3] Brown Univ, Hasbro Childrens Hosp, Dept Pediat, Div Pediat Crit Care Med,Warren Alpert Med Sch, Providence, RI USA

[4] NIH, Mol & Clin Nutr Sect, Digest Dis Branch, Intramural Res Program,Natl Inst Diabet & Digest &, Bethesda, MD USA

[5] 593 Eddy St,Potter 115, Providence, RI 02903 USA

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2023年 / 45卷 / 07期

基金：

美国国家卫生研究院;

关键词：

sickle cell; vitamin C; deformability; OXIDATIVE STRESS; FRAGILITY; MOUSE;

D O I：

10.1097/MPH.0000000000002631

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Red cell rigidity is common in sickle cell disease (SCD). The contribution of oxidative stress on deformability remains unknown. This study investigated red blood cell (RBC) vitamin C concentrations in pediatric SCD (n=43) compared with healthy controls (n=23) and developed a protocol to raise RBC vitamin C concentrations to measure the effect on deformability. Sickle cell RBC vitamin C concentrations seem low (20.5 mu M, SD: 16.2 vs. 51.7 mu M, SD: 15.8; P<0.0001). Vitamin C can be successfully loaded into sickle cell RBCs but seems to have minimal effect on deformability. Future studies are needed to understand the clinical implications of vitamin C deficiency in pediatric SCD.

引用

页码：e936 / e939

页数：4

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