Multicenter retrospective study of stereotactic body radiotherapy for patients with previously untreated initial small hepatocellular carcinoma

被引:1
|
作者
Doi, Yoshiko [1 ,2 ]
Nagata, Yasushi [1 ,2 ,17 ]
Matsumoto, Yasuo [3 ]
Numata, Kazushi [4 ]
Sasaki, Ryu [5 ]
Yamada, Takashi [6 ]
Igaki, Hiroshi [7 ]
Imagumbai, Toshiyuki [8 ]
Katoh, Norio [9 ]
Yoshitake, Tadamasa [10 ]
Shimizuguchi, Takuya [11 ]
Fujioka, Den [12 ]
Inoue, Minoru [13 ]
Koide, Yutaro [14 ]
Kimura, Tomoki [15 ]
Ito, Yoshinori [16 ]
机构
[1] Hiroshima High Precis Radiotherapy Canc Ctr, Hiroshima, Japan
[2] Hiroshima Univ, Inst Biomed & Hlth Sci, Dept Radiat Oncol, Hiroshima, Japan
[3] Niigata Canc Ctr Hosp, Dept Radiat Oncol, Niigata, Japan
[4] Yokohama City Univ, Dept Gastroenterol, Med Ctr, Yokohama, Japan
[5] Nagasaki Univ, Dept Gastroenterol & Hepatol, Grad Sch Biomed Sci, Nagasaki, Japan
[6] Yamanashi Univ Hosp, Dept Radiat Oncol, Yamanashi, Japan
[7] Natl Canc Ctr Hosp Japan, Dept Radiat Oncol, Tokyo, Japan
[8] Kobe City Med Ctr Gen Hosp, Dept Radiat Oncol, Kobe, Hyogo, Japan
[9] Hokkaido Univ, Dept Radiat Oncol, Fac Med, Sapporo, Japan
[10] Kyusyu Univ Hosp, Dept Radiat Oncol, Fukuoka, Japan
[11] Komagome Hosp, Tokyo Metropolitan Canc & Infect Dis Ctr, Dept Radiat Oncol, Tokyo, Japan
[12] Tsukuba Univ Hosp, Dept Radiat Oncol, Ibaraki, Japan
[13] Kyoto Univ Hosp, Dept Radiat Oncol, Kyoto, Japan
[14] Aichi Canc Ctr Hosp, Dept Radiat Oncol, Nagoya, Japan
[15] Kochi Univ Hosp, Dept Radiat Oncol, Kochi, Japan
[16] Showa Univ, Dept Radiat Oncol, Sch Med, Tokyo, Japan
[17] Hiroshima Univ, Grad Sch Biomed Sci, Dept Radiat Oncol, 1-2-3, Kasumi,Minami Ku, Hiroshima 7348551, Japan
关键词
initial hepatocellular carcinoma; multicenter study; previously untreated hepatocellular carcinoma; retrospective study; stereotactic body radiotherapy; unsuitability for or refusal of standard treatment; VS. RADIOFREQUENCY ABLATION; SURGICAL RESECTION; RADIATION-THERAPY; MANAGEMENT; PHASE-2; TRIAL;
D O I
10.1111/hepr.13908
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
AimWe aimed to verify the therapeutic efficacy and safety of stereotactic body radiotherapy (SBRT) for previously untreated initial small hepatocellular carcinoma (HCC) in a multicenter, retrospective study. MethodsPatients who underwent SBRT for HCC at the Japanese Society of Clinical Oncology (JCOG) member hospitals in Japan between July 2013 and December 2017 and met the following eligibility criteria were included: (1) initial HCC; (2) <= 3 nodules, <= 5 cm in diameter; (3) Child-Pugh score of A or B; and (4) unsuitability for or refusal of standard treatment. We analyzed the overall survival, recurrence-free survival, and cumulative incidence of local recurrence rate, and adverse events directly related to SBRT. ResultsSeventy-three patients with 79 lesions from 14 hospitals were analyzed. The median age was 77 years (range: 50-89 years), and the median tumor size was 23 mm (range: 6-50 mm). The median radiation dose was 40 Gy (range: 35-60 Gy) in five fractions (range: 4-8). The median follow-up period was 45 months (range: 0-103 months). The 3-year overall survival, recurrence-free survival, and cumulative incidence of local recurrence rates were 69.9% (95% CI: 58.7%-81%), 57.9% (95% CI: 45.2%-70.5%), and 20.0% (95% CI: 11.2%-30.5%), respectively. Four cases (5.5%) of adverse events of grade 3 or higher were reported: three cases of grade 3 and one case of grade 4 (duodenal ulcer). No grade 5 toxicities were observed. ConclusionSBRT is a promising treatment modality, particularly for small HCCs, as they are not suitable for standard treatment.
引用
收藏
页码:749 / 760
页数:12
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