NFAT signaling dysregulation in cancer: Emerging roles in cancer stem cells

被引：8
|
作者：
Lin, Yibin [1 ]
Song, Yifu [1 ]
Zhang, Yaochuan [1 ]
Shi, Mengwu [1 ]
Hou, Ana [2 ,3 ]
Han, Sheng [1 ,4 ]
机构：
[1] China Med Univ, Hosp 1, Dept Neurosurg, Shenyang 110001, Peoples R China
[2] China Med Univ, Dept Pediat, Shengjing Hosp, Shenyang 110001, Peoples R China
[3] China Med Univ, Dept Pediat, Shengjing Hosp, Shenyang, Peoples R China
[4] China Med Univ, Hosp 1, Dept Neurosurg, Shenyang, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 165卷
基金：
中国国家自然科学基金;
关键词：
NFAT; Cancer stem cell (CSC); Calcineurin-NFAT signaling; NFAT regulation; Cancer development and progression; Glioma; TRANSCRIPTION FACTOR NFAT1; LYMPHOCYTE-SPECIFIC FACTORS; REGULATORY T-CELLS; NUCLEAR FACTOR; KAPPA-B; C-MYC; INTERLEUKIN-2; GENE; CYCLOSPORINE-A; CA2+ SENSOR; LUNG-CANCER;
D O I：
10.1016/j.biopha.2023.115167
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The nuclear factor of activated T cells (NFAT) was first identified as a transcriptional regulator of activated T cells. The NFAT family is involved in the development of tumors. Furthermore, recent evidence reveals that NFAT proteins regulate the development of inflammatory and immune responses. New discoveries have also been made about the mechanisms by which NFAT regulates cancer progression through cancer stem cells (CSC). Here, we discuss the role of the NFAT family in the immune system and various cancer types.
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收藏
页数：14
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