Generation of two isogenic sickle cell disease induced pluripotent stem cell lines from testicular fibroblasts

被引：0
|
作者：
Harancher, Mitchell R. [1 ,2 ]
Sukhwani, Meena [2 ]
Castro, Carlos A. [2 ]
Hsieh, Michael H. [3 ]
Orwig, Kyle E. [1 ,2 ]
机构：
[1] Univ Pittsburgh, Mol Genet & Dev Biol Grad Program, Sch Med, Pittsburgh, PA 15213 USA
[2] Univ Pittsburgh, Sch Med, Magee Womens Res Inst, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA 15213 USA
[3] Childrens Natl Hosp, Washington, DC USA
来源：
STEM CELL RESEARCH | 2023年 / 73卷
关键词：
D O I：
10.1016/j.scr.2023.103257
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Curative bone marrow transplantation (BMT) therapies for sickle cell disease (SCD) can cause infertility. The Fertility Preservation Program (FPP) in Pittsburgh cryopreserves testicular tissues for SCD patients prior to BMT in anticipation that those tissues can be thawed in the future and matured to produce sperm. Here, we generated and validated two isogenic patient-derived induced pluripotent stem cell (iPSC) lines from testicular biopsy fibroblasts of a 12-year-old SCD patient.
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页数：5
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