Distinct roles of telomerase activity in age-related chronic diseases: An update literature review

被引：2

作者：

Wang, Xiaodan ^{[1
]}

Deng, Hao ^{[1
]}

Lin, Jingyi ^{[1
]}

Zhang, Kai ^{[1
]}

Ni, Jingyu ^{[1
]}

Li, Lan ^{[2
]}

Fan, Guanwei ^{[1
,3
]}

机构：

[1] Tianjin Univ Tradit Chinese Med, Natl Clin Res Ctr Chinese Med Acupuncture & Moxibu, Tianjin Key Lab Translat Res TCM Prescript & Syndr, Med Expt Ctr,Teaching Hosp 1, Tianjin 300381, Peoples R China

[2] Tianjin Univ Tradit Chinese Med, Key Lab Pharmacol Tradit Chinese Med Formulae, State Key Lab Modern Chinese Med, Minist Educ, Tianjin 301617, Peoples R China

[3] Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, 88 Changling Rd, Tianjin, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 167卷

基金：

中国国家自然科学基金;

关键词：

Telomerase activity; Aging; Age-related degenerative diseases; Therapeutic prospect; ISCHEMIA-REPERFUSION INJURY; REVERSE-TRANSCRIPTASE; ALZHEIMERS-DISEASE; CATALYTIC SUBUNIT; CELL SENESCENCE; HUMAN ATHEROSCLEROSIS; OXIDATIVE STRESS; HEART-FAILURE; LIVER-DISEASE; HEXOKINASE-II;

D O I：

10.1016/j.biopha.2023.115553

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Although telomerase has low activity in somatic quiescent cells, it plays an significant roles in regenerative cells such as endothelial cells, hepatocytes, epithelial cells, and hemocytes. Telomerase activity and telomere length are critical factors in age-related chronic diseases as they are closely related to cell senescence. However, whether telomerase activity plays a key role in disease progression or whether the role of telomerase is unified among different diseases are unresolved. Considering that aging is the most important risk factor for neurodegenerative and metabolic diseases, this article will analyze the evidence, mechanism, and therapeutic potential of telomerase activity in several chronic disease, including type 2 diabetes, neurodegenerative diseases, atherosclerosis, heart failure and non-alcoholic fatty liver disease, in order to provide clues for the use of telomerase activity to target the treatment of age-related chronic diseases.

引用

页数：10

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