Fluorinated Peptide Nanoscale Hydrogel Accelerates Wound Healing via pH and Oxygen Microenvironment Regulation

被引:1
|
作者
Mei, Leixia [1 ]
Yang, Haihong [1 ]
Dong, Weimiao [1 ]
Liu, Min [1 ,2 ]
Han, Jun [1 ,3 ]
机构
[1] Liaocheng Univ, Inst Biopharmaceut Res, Liaocheng 252059, Peoples R China
[2] Liaocheng Univ, Sch Chem & Chem Engn, Liaocheng 252059, Peoples R China
[3] Liaocheng High Tech Biotechnol Co Ltd, Liaocheng 252059, Peoples R China
基金
中国国家自然科学基金;
关键词
wound healing; wound pH; oxygen microenvironment; nanofiber network; fluorinated peptide hydrogel; ANTICANCER; BIOFILMS; CELLS;
D O I
10.1021/acsanm.3c04523
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
The abnormal levels of pH and oxygen (O-2) in the wound microenvironment impeded wound healing, and their regulation remains a challenge. Thus, a wound dressing with pH and O-2-regulating capacity is urgently desired. Here, we designed and prepared a fluorinated peptide hydrogel wound dressing to regulate the pH and O-2 microenvironment of the wound site. Fluorinated peptides with the (naphthalene-2-ly)-Gly-(5f)Phe-(5f)Phe-Tyr-Arg-Gly-Asp sequence (F-5-Pep) could self-assemble to a nanofiber network in a weak acidic buffer (pH = 6.0), which is similar to the pH of human skin. The F-5-Pep hydrogel can maintain pH levels at 6.0-7.3 for 24 h and continuously release O-2 for 4 h. The blood coagulation and hemostasis assay showed that the F-5-Pep hydrogel significantly accelerated blood clotting speed in vitro and rapidly controlled hemorrhage in a mouse liver hemorrhage model. In vitro cell migration assays and in vivo animal experiments confirmed that the F-5-Pep hydrogel can promote cell migration and wound healing. In summary, this work might provide an effective treatment strategy for wounds and develop advanced wound-healing materials.
引用
收藏
页码:382 / 393
页数:12
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