Sex differences in CD8+ T cell responses during adaptive immunity

被引：2

作者：

Layug, Paul Jerard ^{[1
,2
]}

Vats, Harman ^{[2
,3
]}

Kannan, Kamali ^{[2
,4
]}

Arsenio, Janilyn ^{[1
,2
,3
,4
]}

机构：

[1] Univ Manitoba, Max Rady Coll Med, Dept Internal Med, Winnipeg, MB, Canada

[2] Univ Manitoba, Manitoba Ctr Prote & Syst Biol, Winnipeg, MB, Canada

[3] Univ Manitoba, Max Rady Coll Med, Winnipeg, MB, Canada

[4] Univ Manitoba, Max Rady Coll Med, Rady Fac Hlth Sci, Winnipeg, MB, Canada

来源：

WIRES MECHANISMS OF DISEASE | 2024年 / 16卷 / 05期

关键词：

autoimmunity; cancer; CD8+T cell; exhaustion; infection; sex bias; T cell immunity; LYMPHOCYTE SUBSETS; X-CHROMOSOME; EFFECTOR; EXHAUSTION; AGE; DIFFERENTIATION; FEMALES; CANCER; SUSCEPTIBILITY; EXPRESSION;

D O I：

10.1002/wsbm.1645

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Biological sex is an important variable that influences the immune system's susceptibility to infectious and non-infectious diseases and their outcomes. Sex dimorphic features in innate and adaptive immune cells and their activities may help to explain sex differences in immune responses. T lymphocytes in the adaptive immune system are essential to providing protection against infectious and chronic inflammatory diseases. In this review, T cell responses are discussed with focus on the current knowledge of biological sex differences in CD8(+) T cell mediated adaptive immune responses in infectious and chronic inflammatory diseases. Future directions aimed at investigating the molecular and cellular mechanisms underlying sex differences in diverse T cell responses will continue to underscore the significance of understanding sex differences in protective immunity at the cellular level, to induce appropriate T cell-based immune responses in infection, autoimmunity, and cancer. This article is categorized under: Immune System Diseases > Molecular and Cellular Physiology Infectious Diseases > Molecular and Cellular Physiology

引用

页数：13

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