Ulcerative Colitis-associated Spondyloarthritis Successfully Treated with Infliximab in the Absence of Enhanced TNF-α Responses

被引：0
|
作者：
Fujita, Shunsuke [1 ]
Honjo, Hajime [1 ]
Takada, Ryutaro [1 ]
Hara, Akane [1 ]
Masuta, Yasuhiro [1 ]
Otsuka, Yasuo [1 ]
Handa, Kohei [1 ]
Minaga, Kosuke [1 ]
Tsuji, Shigeyoshi [2 ]
Kudo, Masatoshi [1 ]
Watanabe, Tomohiro [1 ]
机构：
[1] Kindai Univ, Fac Med, Dept Gastroenterol & Hepatol, Higashiosaka, Japan
[2] Nippon Life Hosp, Dept Orthopaed Surg, Osaka, Japan
来源：
INTERNAL MEDICINE | 2023年 / 62卷 / 17期
基金：
日本学术振兴会;
关键词：
spondyloarthritis; ulcerative colitis; IL-6; TNF; infliximab; REGULATORY T-CELLS; ACTIVATION; APOPTOSIS; THERAPY; BINDING; NUMBER;
D O I：
10.2169/internalmedicine.1182-22
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Although concurrent occurrence of spondyloarthritis (SpA) and ulcerative colitis (UC) is sometimes seen, the profiles of cytokines have been poorly understood in UC-associated SpA. We herein report a case of UCassociated SpA successfully treated with infliximab (IFX). Profiles of cytokines in the serum and colonic mucosa were characterized by an enhanced expression of IL-6 but not tumor necrosis factor (TNF)-alpha. Successful induction of remission by IFX was associated with the downregulation of IL-6 expression but no significant alteration in TNF-alpha expression. These findings suggest that some cases of UC-associated SpA might be driven by IL-6, and IFX might be effective in cases lacking enhanced TNF-alpha responses.
引用
收藏
页码：2493 / 2497
页数：5
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