Preclinical evaluation of PHH-1V vaccine candidate against SARS-CoV-2 in non-human primates

被引：5

作者：

Prenafeta, Antoni ^{[1
]}

Bech-Sabat, Gregori ^{[1
]}

Moros, Alexandra ^{[1
]}

Barreiro, Antonio ^{[1
]}

Fernandez, Alex ^{[1
]}

Canete, Manuel ^{[1
]}

Roca, Merce ^{[1
]}

Gonzalez-Gonzalez, Luis ^{[1
]}

Garriga, Carme ^{[1
]}

Confais, Joachim ^{[2
]}

Toussenot, Marion ^{[2
]}

Contamin, Hugues ^{[2
]}

Pizzorno, Andres ^{[3
]}

Rosa-Calatrava, Manuel ^{[3
,4
]}

Pradenas, Edwards ^{[5
]}

Marfil, Silvia ^{[5
]}

Blanco, Julia ^{[5
,6
]}

Rica, Paula Cebollada ^{[7
]}

Sistere-Oro, Marta ^{[7
]}

Meyerhans, Andreas ^{[7
,8
]}

Lorca, Cristina ^{[9
,10
]}

Segales, Joaquim ^{[9
,11
]}

Prat, Teresa ^{[1
]}

March, Ricard ^{[1
]}

Ferrer, Laura ^{[1
]}

机构：

[1] HIPRA, Avda Selva 135, Amer Girona 17170, Spain

[2] Cynbiose, 1 Ave Bourgelat, F-69280 Marcy Ietoile, France

[3] Univ Claude Bernard Lyon 1, Univ Lyon, CIRI Ctr Int Rech Infectiol, Team VirPath,INSERM,U1111,CNRS,UMR5308,ENS Lyon, F-69007 Lyon, France

[4] Univ Lyon, Univ Claude Bernard Lyon 1, Fac Med RTH Laennec, VirNext, Lyon, France

[5] UAB, AIDS Res Inst, Germans Trias & Pujol Res Inst IGTP, IrsiCaixa, Can Ruti Campus, Badalona 08916, Spain

[6] Univ Vic Cent Univ Catalonia UV UCC, Vic 08500, Catalonia, Spain

[7] Univ Pompeu Fabra UPF, Dept Expt & Hlth Sci, Infect Biol Lab, Barcelona 08003, Spain

[8] ICREA Catalan Inst Res & Adv Studies, Pg Lluis Co 23, Barcelona 08010, Spain

[9] Campus Univ Autonoma Barcelona UAB, Ctr Recerca Sanitat Anim CReSA, Unitat Mixta Invest IRTA UAB Sanitat Anim, Bellaterra 08193, Spain

[10] Campus Univ Autonoma Barcelona UAB, Ctr Recerca Sanitat Anim CReSA, IRTA, Programa Sanitat Anim, Bellaterra 08193, Spain

[11] Univ Autonoma Barcelona, Dept Sanitat & Anat Anim, Fac Vet, Cerdanyola Del Valles 08193, Spain

来源：

ISCIENCE | 2023年 / 26卷 / 07期

关键词：

COVID-19;

D O I：

10.1016/j.isci.2023.107224

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

SARS-CoV-2 emerged in December 2019 and quickly spread worldwide, continu-ously striking with an unpredictable evolution. Despite the success in vaccine pro-duction and mass vaccination programs, the situation is not still completely controlled, and therefore accessible second-generation vaccines are required to mitigate the pandemic. We previously developed an adjuvanted vaccine candi-date coded PHH-1V, based on a heterodimer fusion protein comprising the RBD domain of two SARS-CoV-2 variants. Here, we report data on the efficacy, safety, and immunogenicity of PHH-1V in cynomolgus macaques. PHH-1V prime-boost vaccination induces high levels of RBD-specific IgG binding and neutralizing anti-bodies against several SARS-CoV-2 variants, as well as a balanced Th1/Th2 cellular immune response. Remarkably, PHH-1V vaccination prevents SARS-CoV-2 replication in the lower respiratory tract and significantly reduces viral load in the upper respiratory tract after an experimental infection. These results highlight the potential use of the PHH-1V vaccine in humans, currently undergo-Phase III clinical trials.

引用

下载

页数：25

共 50 条

[21] Neuropathology and virus in brain of SARS-CoV-2 infected non-human primates
Ibolya Rutkai
Meredith G. Mayer
Linh M. Hellmers
Bo Ning
Zhen Huang
Christopher J. Monjure
Carol Coyne
Rachel Silvestri
Nadia Golden
Krystle Hensley
Kristin Chandler
Gabrielle Lehmicke
Gregory J. Bix
Nicholas J. Maness
Kasi Russell-Lodrigue
Tony Y. Hu
Chad J. Roy
Robert V. Blair
Rudolf Bohm
Lara A. Doyle-Meyers
Jay Rappaport
Tracy Fischer
Nature Communications, 13
[22] Neuropathology and virus in brain of SARS-CoV-2 infected non-human primates
Rutkai, Ibolya
Mayer, Meredith G.
Hellmers, Linh M.
Ning, Bo
Huang, Zhen
Monjure, Christopher J.
Coyne, Carol
Silvestri, Rachel
Golden, Nadia
Hensley, Krystle
Chandler, Kristin
Lehmicke, Gabrielle
Bix, Gregory J.
Maness, Nicholas J.
Russell-Lodrigue, Kasi
Hu, Tony Y.
Roy, Chad J.
Blair, Robert, V
Bohm, Rudolf
Doyle-Meyers, Lara A.
Rappaport, Jay
Fischer, Tracy
NATURE COMMUNICATIONS, 2022, 13 (01)
[23] A pathogen-like antigen-based vaccine confers immune protection against SARS-CoV-2 in non-human primates
Guo, Chang
Peng, Yanan
Lin, Lin
Pan, Xiaoyan
Fang, Mengqi
Zhao, Yun
Bao, Keyan
Li, Runhan
Han, Jianbao
Chen, Jiaorong
Song, Tian-Zhang
Feng, Xiao-Li
Zhou, Yahong
Zhao, Gan
Zhang, Leike
Zheng, Yongtang
Zhu, Ping
Hang, Haiying
Zhang, Linqi
Hua, Zhaolin
Deng, Hongyu
Hou, Baidong
CELL REPORTS MEDICINE, 2021, 2 (11)
[24] Synthetic multiantigen MVA vaccine COH04S1 protects against SARS-CoV-2 in Syrian hamsters and non-human primates
Chiuppesi, Flavia
Nguyen, Vu H.
Park, Yoonsuh
Contreras, Heidi
Karpinski, Veronica
Faircloth, Katelyn
Nguyen, Jenny
Kha, Mindy
Johnson, Daisy
Martinez, Joy
Iniguez, Angelina
Zhou, Qiao
Kaltcheva, Teodora
Frankel, Paul
Kar, Swagata
Sharma, Ankur
Andersen, Hanne
Lewis, Mark G.
Shostak, Yuriy
Wussow, Felix
Diamond, Don J.
NPJ VACCINES, 2022, 7 (01)
[25] Synthetic multiantigen MVA vaccine COH04S1 protects against SARS-CoV-2 in Syrian hamsters and non-human primates
Flavia Chiuppesi
Vu H. Nguyen
Yoonsuh Park
Heidi Contreras
Veronica Karpinski
Katelyn Faircloth
Jenny Nguyen
Mindy Kha
Daisy Johnson
Joy Martinez
Angelina Iniguez
Qiao Zhou
Teodora Kaltcheva
Paul Frankel
Swagata Kar
Ankur Sharma
Hanne Andersen
Mark G. Lewis
Yuriy Shostak
Felix Wussow
Don J. Diamond
npj Vaccines, 7
[26] Preclinical Establishment of a Divalent Vaccine against SARS-CoV-2
Hevesi, Zsofia
Gerges, Daniela Anna
Kapps, Sebastian
Freire, Raimundo
Schmidt, Sophie
Pollak, Daniela D.
Schmetterer, Klaus
Frey, Tobias
Lang, Rita
Winnicki, Wolfgang
Schmidt, Alice
Harkany, Tibor
Wagner, Ludwig
VACCINES, 2022, 10 (04)
[27] Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates
Corbett, Kizzmekia S.
Flynn, Barbara
Foulds, Kathryn E.
Francica, Joseph R.
Boyoglu-Barnum, Seyhan
Werner, Anne P.
Flach, Britta
O'Connell, Sarah
Bock, Kevin W.
Minai, Mahnaz
Nagata, Bianca M.
Andersen, Hanne
Martinez, David R.
Noe, Amy T.
Douek, Naomi
Donaldson, Mitzi M.
Nji, Nadesh N.
Alvarado, Gabriela S.
Edwards, Darin K.
Flebbe, Dillon R.
Lamb, Evan
Doria-Rose, Nicole A.
Lin, Bob C.
Louder, Mark K.
O'Dell, Sijy
Schmidt, Stephen D.
Phung, Emily
Chang, Lauren A.
Yap, Christina
Todd, John-Paul M.
Pessaint, Laurent
Van Ry, Alex
Browne, Shanai
Greenhouse, Jack
Putman-Taylor, Tammy
Strasbaugh, Amanda
Campbell, Tracey-Ann
Cook, Anthony
Dodson, Alan
Steingrebe, Katelyn
Shi, Wei
Zhang, Yi
Abiona, Olubukola M.
Wang, Lingshu
Pegu, Amarendra
Yang, Eun Sung
Leung, Kwanyee
Zhou, Tongqing
Teng, I-Ting
Widge, Alicia
NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (16): : 1544 - 1555
[28] Development of DNA Vaccine Candidate against SARS-CoV-2
Wang, Xingyun
Rcheulishvili, Nino
Cai, Jie
Liu, Cong
Xie, Fengfei
Hu, Xing
Yang, Nuo
Hou, Mengqi
Papukashvili, Dimitri
He, Yunjiao
Wang, Peng George
VIRUSES-BASEL, 2022, 14 (05):
[29] Impact of variants of concern on SARS-CoV-2 viral dynamics in non-human primates
Marc, Aurelien
Marlin, Romain
Donati, Flora
Prague, Melanie
Kerioui, Marion
Herate, Cecile
Alexandre, Marie
Dereuddre-bosquet, Nathalie
Bertrand, Julie
Contreras, Vanessa
Behillil, Sylvie
Maisonnasse, Pauline
van der Werf, Sylvie
Le Grand, Roger
Guedj, Jeremie
PLOS COMPUTATIONAL BIOLOGY, 2023, 19 (08)
[30] Neuronal Death and Inflammation in Brain of SARS-CoV-2 Infected Non-Human Primates
Mayer, Meredith G.
Rutkai, Ibolya
Hellmers, Linh M.
Ning, Bo
Huang, Zhen
Monjure, Christopher J.
Coyne, Carol
Silvestri, Rachel
Golden, Nadia
Hensley, Krystle
Chandler, Kristin
Lehmicke, Gabrielle
Bix, Gregory J.
Maness, Nicholas J.
Russell-Lodrigue, Kasi
Hu, Tony Y.
Roy, Chad J.
Blair, Robert V.
Bohm, Rudolf
Doyle-Meyers, Lara A.
Fischer, Tracy
AMERICAN JOURNAL OF PATHOLOGY, 2021, 191 (10 S): : S2 - S3

← 1 2 3 4 5 →