Coupling of Cortical Hyperintense Signals and Increased Glucose Metabolism in a Case of Anti-GABAA Receptor Antibody-associated Encephalitis

被引：1
|
作者：
Hashimoto, Kentaro [1 ]
Nakamura, Takumi [1 ]
Fujita, Yukio [1 ]
Furuta, Minori [1 ]
Makioka, Kouki [1 ]
Shimoda, Yuki [2 ]
Iizuka, Takahiro [3 ]
Ikeda, Yoshio [1 ]
机构：
[1] Gunma Univ, Grad Sch Med, Dept Neurol, Maebashi, Japan
[2] Gunma Univ, Grad Sch Med, Dept Diagnost Pathol, Maebashi, Japan
[3] Kitasato Univ, Sch Med, Dept Neurol, Tokyo, Japan
来源：
INTERNAL MEDICINE | 2023年 / 62卷 / 23期
关键词：
18F-fluorodeoxyglucose-positron emission tomography; anti-GABAA receptor antibody; autoimmune encephalitis; status epilepticus; paraneoplastic syndrome; thymoma;
D O I：
10.2169/internalmedicine.1535-22
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We herein report a case of anti-gamma aminobutyric acid type A receptor antibody-associated encephalitis (anti-GABAA-RE) with progressive aphasia and generalized tonicclonic seizures. Cerebral magnetic resonance imaging (MRI) showed cortical brain lesions coupled with hypermetabolism on fluorodeoxyglucose-positron emission tomography. After two courses of methylprednisolone pulse therapy, improvements in neu-rological symptoms without sequelae and the total disappearance of MRI lesions were observed. Upon en-countering patients with refractory status epilepticus, multifocal cerebral MRI lesions, and suspected autoim-mune encephalitis, especially in cases with thymoma, it would be prudent to suspect anti-GABAA-RE and consider the evaluation of anti-GABAA receptor antibody and methylprednisolone pulse therapy.
引用
收藏
页码：3545 / 3548
页数：4
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