Research Progress of Indole Alkaloids: Targeting MAP Kinase Signaling Pathways in Cancer Treatment

被引：4

作者：

Al Amin, Md. ^{[1
]}

Bin Emran, Talha ^{[1
,2
,3
]}

Khan, Jishan ^{[4
]}

Zehravi, Mehrukh ^{[5
]}

Sharma, Indu ^{[6
]}

Patil, Anasuya ^{[7
]}

Gupta, Jeetendra Kumar ^{[8
]}

Jeslin, D. ^{[9
]}

Krishnan, Karthickeyan ^{[10
]}

Das, Rajib ^{[11
]}

Nainu, Firzan ^{[12
]}

Ahmad, Irfan ^{[13
]}

Wilairatana, Polrat ^{[14
]}

机构：

[1] Daffodil Int Univ, Fac Allied Hlth Sci, Dept Pharm, Dhaka 1207, Bangladesh

[2] Brown Univ, Warren Alpert Med Sch, Dept Pathol & Lab Med, Providence, RI 02912 USA

[3] Brown Univ, Legorreta Canc Ctr, Providence, RI 02912 USA

[4] Int Islamic Univ Chittagong, Dept Pharm, Chittagong 4318, Bangladesh

[5] Buraydah Private Coll, Coll Dent & Pharm, Dept Clin Pharm, Buraydah 51418, Saudi Arabia

[6] Career Point Univ, Dept Phys, Hamirpur 176041, Himachal Prades, India

[7] KLE Coll Pharm, Dept Pharmaceut, Bengaluru 560010, Karnataka, India

[8] GLA Univ, Inst Pharmaceut Res, Dept Pharmacol, Mathura 281406, Uttar Pradesh, India

[9] Sree Balaji Med Coll & Hosp Campus, Bharath Inst Higher Educ & Res, Dept Pharmaceut, Chennai 600044, Tamil Nadu, India

[10] Vels Inst Sci Technol & Adv Studies VISTAS, Sch Pharmaceut Sci, Dept Pharm Practice, Chennai 600117, Tamil Nadu, India

[11] Univ Dhaka, Fac Pharm, Dept Pharm, Dhaka 1000, Bangladesh

[12] Hasanuddin Univ, Fac Pharm, Dept Pharm, Makassar 90245, Indonesia

[13] King Khalid Univ, Coll Appl Med Sci, Dept Clin Lab Sci, Abha 61411, Saudi Arabia

[14] Mahidol Univ, Fac Trop Med, Dept Clin Trop Med, Bangkok 10400, Thailand

来源：

CANCERS | 2023年 / 15卷 / 22期

关键词：

apoptosis; clinical studies; cancer; indole alkaloids; MAPK; N-TERMINAL KINASE; CELL LUNG-CANCER; PHASE-II; MEDIATED APOPTOSIS; IN-VITRO; EVODIAMINE; AUTOPHAGY; ACTIVATION; DEATH; 3,3'-DIINDOLYLMETHANE;

D O I：

10.3390/cancers15225311

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Simple Summary Cancer is a major global health concern, with the Mitogen-activated protein kinase (MAPK) pathway playing a crucial role in cancerous diseases. Indole alkaloids, such as vincristine and evodiamine, have been extensively studied for their potential in cancer treatment. These naturally occurring indole alkaloids have strong anticancer properties, and research is ongoing to develop new anticancer small molecules. The current review aims to evaluate how indole alkaloids affect the MAPK signaling pathway in cancer treatment and focus on advancements in the role of indole alkaloids. The review also highlights clinical trials with indole alkaloids in cancer treatment.Abstract Cancer is the leading cause of morbidity and mortality in people throughout the world. There are many signaling pathways associated with cancerous diseases, from which the Mitogen-activated protein kinase (MAPK) pathway performs a significant role in this regard. Apoptosis and proliferation are correlated with MAPK signaling pathways. Plenty of experimental investigations were carried out to assess the role of indole alkaloids in MAPK-mediated cancerous diseases. Previous reports established that indole alkaloids, such as vincristine and evodiamine are useful small molecules in cancer treatment via the MAPK signaling system. Indole alkaloids have the anticancer potential through different pathways. Vincristine and evodiamine are naturally occurring indole alkaloids that have strong anticancer properties. Additionally, much research is ongoing or completed with molecules belonging to this group. The current review aims to evaluate how indole alkaloids affect the MAPK signaling pathway in cancer treatment. Additionally, we focused on the advancement in the role of indole alkaloids, with the intention of modifying the MAPK signaling pathways to investigate potential new anticancer small molecules. Furthermore, clinical trials with indole alkaloids in cancer treatment are also highlighted.

引用

页数：20

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