Fluctuating selection and the determinants of genetic variation

被引：6

作者：

Johnson, Olivia L. ^{[1
]}

Tobler, Raymond ^{[1
,2
]}

Schmidt, Joshua M. ^{[3
,4
]}

Huber, Christian D. ^{[1
,5
]}

机构：

[1] Univ Adelaide, Australian Ctr Ancient DNA, Sch Biol Sci, Adelaide, Australia

[2] Australian Natl Univ, Evolut Cultural Divers Initiat, Canberra, Australia

[3] Flinders Hlth & Med Res Inst FHMRI Eye & Vis, Bedford Pk, Adelaide, Australia

[4] Flinders Univ S Australia, Bedford Pk, Adelaide, Australia

[5] Penn State Univ, Dept Biol, University Pk, PA 16801 USA

来源：

TRENDS IN GENETICS | 2023年 / 39卷 / 06期

基金：

澳大利亚研究理事会;

关键词：

TERM BALANCING SELECTION; BENEFICIAL MUTATIONS; NATURAL-POPULATIONS; MOLECULAR EVOLUTION; SOFT SWEEPS; POLYMORPHISM; DOMINANCE; ALLELES; ADAPTATION; EPISTASIS;

D O I：

10.1016/j.tig.2023.02.004

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Recent studies of cosmopolitan Drosophila populations have found hundreds to thousands of genetic loci with seasonally fluctuating allele frequencies, bringing temporally fluctuating selection to the forefront of the historical debate surround-ing the maintenance of genetic variation in natural populations. Numerous mech-anisms have been explored in this longstanding area of research, but these exciting empirical findings have prompted several recent theoretical and experi-mental studies that seek to better understand the drivers, dynamics, and ge-nome-wide influence of fluctuating selection. In this review, we evaluate the latest evidence for multilocus fluctuating selection in Drosophila and other taxa, highlighting the role of potential genetic and ecological mechanisms in maintain-ing these loci and their impacts on neutral genetic variation.

引用

页码：491 / 504

页数：14

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