SPATIAL POSITIONING AND MATRIX PROGRAMS OF SYNOVIAL FIBROBLASTS UNDERPIN IMMUNE CELL ORGANISATION AND SYNOVIAL TISSUE PATHOTYPE

被引:0
|
作者
Nisa, P. I. Reis [1 ]
Mahony, C. [1 ]
Smith, C. [1 ]
Buckley, C. D. [2 ]
Raza, K. [1 ]
Filer, A. [1 ]
Windell, D. [2 ]
Coles, M. [2 ]
Croft, A. [1 ]
机构
[1] Univ Birmingham, Inflammat & Ageing, Birmingham, W Midlands, England
[2] Univ Oxford, Kennedy Inst Rheumatol Res, Oxford, England
关键词
Synovium; -omics; Rheumatoid arthritis;
D O I
10.1136/annrheumdis-2023-eular.6114
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OP0094
引用
收藏
页码:64 / 64
页数:1
相关论文
共 37 条
  • [21] Effects of sulfasalazine and its metabolites on steady state messenger RNA concentrations for inflammatory cytokines, matrix metalloproteinases, and tissue inhibitors of metalloproteinase in rheumatoid synovial fibroblasts
    Minghetti, PP
    Blackburn, WD
    JOURNAL OF RHEUMATOLOGY, 2000, 27 (03) : 653 - 660
  • [22] Degradation of a cartilage-like matrix by rheumatoid synovial fibroblasts is inhibited by gene transfer with a cell surface-targeted plasmin inhibitor.
    van der Laan, WH
    Ronday, HK
    Grimbergen, JM
    Huisman, IGM
    Breedveld, FC
    Koppele, JMT
    Huizinga, TWJ
    Quax, PHA
    Verheijen, JH
    ARTHRITIS AND RHEUMATISM, 1999, 42 (09): : S163 - S163
  • [23] Single-cell multimodal analysis identifies common regulatory programs in synovial fibroblasts of rheumatoid arthritis patients and modeled TNF-driven arthritis
    Marietta Armaka
    Dimitris Konstantopoulos
    Christos Tzaferis
    Matthieu D. Lavigne
    Maria Sakkou
    Anastasios Liakos
    Petros P. Sfikakis
    Meletios A. Dimopoulos
    Maria Fousteri
    George Kollias
    Genome Medicine, 14
  • [24] Single Cell RNA-Sequencing of Rheumatoid Synovial Fibroblasts Reveals a Disease-Associated Spatial Gradient Modulated By Inductive Notch Signaling
    Wei, Kevin
    Korsunsky, Ilya
    Marshall, Jennifer
    Watts, Gerald
    Gao, Anqi
    Blazar, Philip
    Lange, Jeffrey
    Thornhill, Thomas
    Buckley, Chris
    Raychaudhuri, Soumya
    Brenner, Michael
    ARTHRITIS & RHEUMATOLOGY, 2018, 70
  • [25] Single-cell multimodal analysis identifies common regulatory programs in synovial fibroblasts of rheumatoid arthritis patients and modeled TNF-driven arthritis
    Armaka, Marietta
    Konstantopoulos, Dimitris
    Tzaferis, Christos
    Lavigne, Matthieu D.
    Sakkou, Maria
    Liakos, Anastasios
    Sfikakis, Petros P.
    Dimopoulos, Meletios A.
    Fousteri, Maria
    Kollias, George
    GENOME MEDICINE, 2022, 14 (01)
  • [26] Interleukin-4 stimulates rheumatoid synovial fibroblasts to express matrix metalloproteinase-1 (tissue collagenase) and histamine H1 receptor mRNA
    Zenmyo, M
    Hiraoka, K
    Sasaguri, T
    Komiya, S
    Inoue, A
    Morimatsu, M
    Sasaguri, Y
    BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL, 1996, 40 (06): : 1253 - 1260
  • [27] EFFECTS OF LIPID PEROXIDE ON PRODUCTION OF MATRIX METALLOPROTEINASE-1 (TISSUE COLLAGENASE) AND METALLOPROTEINASE-3 (STROMELYSIN) AND TISSUE INHIBITOR METALLOPROTEINASE-1 BY HUMAN RHEUMATOID SYNOVIAL FIBROBLASTS
    HIRAOKA, K
    SASAGURI, Y
    KOMIYA, S
    ZENMYO, M
    INOUE, A
    MORIMATSU, M
    EXPERIMENTAL AND MOLECULAR PATHOLOGY, 1993, 59 (03) : 169 - 176
  • [28] Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model
    Haubruck, Patrick
    Colbath, Aimee C.
    Liu, Yolanda
    Stoner, Shihani
    Shu, Cindy
    Little, Christopher B.
    JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2020, (158):
  • [29] IL-18-induced vascular cell adhesion molecule (VCAM-1) signaling mechanisms in rheumatoid arthritis synovial tissue fibroblasts.
    Park, CC
    Zhu, K
    Morel, JCM
    Koch, AE
    ARTHRITIS AND RHEUMATISM, 2002, 46 (09): : S619 - S619
  • [30] Cyclooxygenase inhibitors enhance the production of tissue inhibitor-1 of metalloproteinases (TIMP-1) and pro-matrix metalloproteinase 1 (proMMP-1) in human rheumatoid synovial fibroblasts
    Takahashi, S
    Inoue, T
    Higaki, M
    Mizushima, Y
    INFLAMMATION RESEARCH, 1997, 46 (08) : 320 - 323