DEVELOPMENT AND VALIDATION OF A NEW VISIBLE SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF FLUCONAZOLE IN THE PRESENCE OF SOME ESSENTIAL OILS

被引：0

作者：

Olariu, Ioana ^{[1
]}

Mut, Ana Maria ^{[1
]}

Vlaia, Vicentiu ^{[2
]}

Craciun, Petru ^{[3
]}

Colgiu, Stefania ^{[4
]}

Szabadai, Zoltan ^{[5
]}

Vlaia, Lavinia ^{[1
]}

Turcu, Eugen Gabriel ^{[6
]}

Lupuliasa, Dumitru ^{[7
]}

Coneac, Georgeta ^{[1
]}

机构：

[1] Victor Babes Univ Med & Pharm, Formulat & Technol Drugs Res Ctr, Dept Pharmaceut Technol 2, 2 Eftimie Murgu Sq, Timisoara 300041, Romania

[2] Victor Babes Univ Med & Pharm, Dept Organ Chem 2, Formulat & Technol Drugs Res Ctr, 2 Eftimie Murgu Sq, Timisoara 300041, Romania

[3] Carol Davila Univ Med & Pharm, Fac Pharm, Dept Drug Ind & Pharmaceut Biotechnol, 6 Traian Vuia St, Bucharest 020956, Romania

[4] Victor Babes Univ Med & Pharm, Doctoral Sch, 2 Eftimie Murgu Sq, Timisoara 300041, Romania

[5] Natl Inst Res Dev Electrochem & Condensed Matter, 144 Dr Aurel Paunescu Podeanu Str, Timisoara 300587, Romania

[6] Carol Davila Univ Med & Pharm, Bagdasar Arseni Clin Emergency Hosp, Dept Plast Surg, 12 Berceni Rd, Bucharest 041915, Romania

[7] Carol Davila Univ Med & Pharm, Fac Pharm, Dept Pharmaceut Technol & Biopharm, 6 Traian Vuia St, Bucharest 020956, Romania

来源：

FARMACIA | 2023年 / 71卷 / 05期

关键词：

visible spectrophotometry; fluconazole; fluconazole-Cu(II) complex; oregano essential oil; VITRO DRUG-RELEASE; TOPICAL DELIVERY; FORMULATION; COMPLEXES; HYDROGELS;

D O I：

10.31925/farmacia.2023.5.19

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This study aimed to develop and validate a visible spectrophotometry analysis method for fluconazole quantification in the presence of some essential oils (cinnamon, oregano and clove essential oil), by forming a coloured complex with Cu2+ ion. For the spectrophotometric method validation the spectra of the fluconazole-Cu(II) complex in the presence of volatile oils were analysed and the wavelengths corresponding to the maximum absorbance values of the complex were determined. Evaluating the precision, linearity, accuracy and robustness of the elaborated visible spectrophotometric method, the obtained values of the specific parameters fell within the limits provided by the standards in force. Linearity was very good for the following fluconazole concentration ranges: 0.268 -2.68 mg/mL for oregano essential oil, 0.2073 -2.073 mg/mL for cinnamon essential oil and 0.2317 -2.317 mg/mL in the case of clove essential oil. The proposed visible spectrophotometric method has been successfully applied for the assay of fluconazole in clove, cinnamon and oregano essential oils.

引用

页码：1045 / 1053

页数：9

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