Methylation Profile of Cancer Testis Antigens in Colorectal Cancer

被引：0
|
作者：
Abu, Nadiah [1 ]
Bakarurraini, Nurul Ainaa Adilah Rus [1 ]
Nasir, Siti Nurmi [1 ]
Ishak, Muhiddin [1 ]
Baharudin, Rashidah [1 ]
Jamal, Rahman [1 ]
Mutalib, Nurul Syakima Ab [1 ]
机构：
[1] Univ Kebangsaan Malaysia, UKM Med Mol Biol Inst UMBI, Kuala Lumpur 56000, Malaysia
来源：
IRANIAN JOURNAL OF IMMUNOLOGY | 2023年 / 20卷 / 01期
关键词：
Tumor -associated Antigen; Cancer -testis Antigen; Epigenetics; Cancer vaccine; Immunotherapy; CANCER/TESTIS ANTIGENS; GENE-EXPRESSION; TUMOR; PROMOTER;
D O I：
10.22034/iji.2023.92600.2171
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Background: Cancer testis antigens (CTAs) are a class of immune-stimulating antigens often overexpressed in many types of cancers. The usage of the CTAs as immunotherapy targets have been widely investigated in different cancers including melanoma, hematological malignancies, and colorectal cancer. Studies have indicated that the epigenetic regulation of the CTAs such as the methylation status may affect the expression of the CTAs. However, the report on the methylation status of the CTAs is conflicting. The general methylation profile of the CTAs, especially in colorectal cancer, is still elusive. Objective: To determine the methylation profile of the selected CTAs in our colorectal cancer patients. Methods: A total of 54 pairs of colorectal cancer samples were Results: We found that most of the CTAs were hypomethylated, and CCNA1 and TMEM108 genes were among the few CTAs that were hypermethylated. Conclusion: Overall, our brief report has managed to show the targets.
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页码：83 / 91
页数：9
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