Targeting cancer testis antigens for biomarkers and immunotherapy in colorectal cancer: Current status and challenges

被引:2
|
作者
Anil Suri [1 ]
Nirmala Jagadish [1 ]
Shikha Saini [1 ]
Namita Gupta [1 ]
机构
[1] Cancer Microarray, Genes and Proteins Laboratory, National Institute of Immunology
关键词
Cancer testis antigens; Colorectal cancer; Testis specific genes; Biomarkers; Immunotherapy;
D O I
暂无
中图分类号
R735.34 [];
学科分类号
100214 ;
摘要
Colorectal cancer ranks third among the estimatedcancer cases and cancer related mortalities in United States in 2014. Early detection and efficient therapy remains a significant clinical challenge for this disease. Therefore, there is a need to identify novel tumor asso-ciated molecules to target for biomarker development and immunotherapy. In this regard, cancer testis antigens have emerged as a potential targets for developing novel clinical biomarkers and immunotherapy for various malignancies. These germ cell specific proteins exhibit aberrant expression in cancer cells and contribute in tumorigenesis. Owing to their unique expression profile and immunogenicity in cancer patients, cancer testis antigens are clinically referred as the most promising tumor associated antigens. Several cancer testis antigens have been studied in colorectal cancer but none of them could be used in clinical practice. This review is an attempt to address the promising cancer testis antigens in colorectal cancer and their possible clinical implications as biomarkers and immunotherapeutic targets with particular focus on challenges and future interventions.
引用
收藏
页码:492 / 502
页数:11
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