Lifestyle and demographic associations with 47 inflammatory and vascular stress biomarkers in 9876 blood donors

被引：5

作者：

Kjerulff, Bertram ^{[1
,2
,3
]}

Dowsett, Joseph ^{[4
]}

Jacobsen, Rikke Louise ^{[4
]}

Gladov, Josephine ^{[1
,2
,3
]}

Larsen, Margit Horup ^{[4
]}

Lundgaard, Agnete Troen ^{[5
]}

Banasik, Karina ^{[5
]}

Westergaard, David ^{[5
,6
]}

Mikkelsen, Susan ^{[1
]}

Dinh, Khoa Manh ^{[1
]}

Hindhede, Lotte ^{[1
]}

Kaspersen, Kathrine Agergard ^{[1
,3
]}

Schwinn, Michael ^{[4
]}

Juul, Anders ^{[6
,7
,8
]}

Poulsen, Betina ^{[4
]}

Lindegaard, Birgitte ^{[6
,9
]}

Pedersen, Carsten Bocker ^{[3
,10
]}

Sabel, Clive Eric ^{[3
,11
,12
]}

Bundgaard, Henning ^{[6
,13
]}

Nielsen, Henriette Svarre ^{[6
,14
,15
,16
]}

Moller, Janne Amstrup ^{[4
]}

Boldsen, Jens Kjaergaard ^{[1
,3
]}

Burgdorf, Kristoffer Solvsten ^{[5
]}

Kessing, Lars Vedel ^{[6
,17
]}

Handgaard, Linda Jenny ^{[4
]}

Thorner, Lise Wegner ^{[4
]}

Didriksen, Maria ^{[4
]}

Nyegaard, Mette ^{[18
]}

Grarup, Niels ^{[19
]}

Odum, Niels ^{[20
]}

Johansson, Paer I. ^{[4
,16
]}

Jennum, Poul ^{[6
,21
]}

Frikke-Schmidt, Ruth ^{[6
,22
]}

Berger, Sanne Schou ^{[23
]}

Brunak, Soren ^{[5
]}

Jacobsen, Soren ^{[6
,24
]}

Hansen, Thomas Folkmann ^{[5
,25
,26
]}

Lundquist, Tine Kirkeskov ^{[4
]}

Hansen, Torben ^{[19
]}

Sorensen, Torben Lykke ^{[6
,27
]}

Sigsgaard, Torben ^{[3
,11
]}

Nielsen, Kaspar Rene ^{[28
]}

Bruun, Mie Topholm ^{[29
]}

Hjalgrim, Henrik ^{[6
,30
,31
,32
]}

Ullum, Henrik ^{[33
]}

Rostgaard, Klaus ^{[30
,31
]}

Sorensen, Erik ^{[4
]}

Pedersen, Ole Birger ^{[6
,34
]}

Ostrowski, Sisse Rye ^{[4
,6
]}

Erikstrup, Christian ^{[1
,2
,3
]}

机构：

[1] Aarhus Univ Hosp, Dept Clin Immunol, Aarhus, Denmark

[2] Aarhus Univ, Dept Clin Med, Aarhus, Denmark

[3] Aarhus Univ, BERTHA Big Data Ctr Environm & Hlth, Aarhus, Denmark

[4] Copenhagen Univ Hosp, Dept Clin Immunol, Rigshosp, Copenhagen, Denmark

[5] Univ Copenhagen, Novo Nord Fdn, Fac Hlth & Med Sci, Translat Dis Syst Biol,Ctr Prot Res, Copenhagen, Denmark

[6] Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark

[7] Copenhagen Univ Hosp, Rigshosp, Dept Growth & Reprod, Copenhagen, Denmark

[8] Univ Copenhagen, Int Ctr Res & Res Training Endocrine Disrupt Male, Rigshosp, Copenhagen, Denmark

[9] Copenhagen Univ Hosp North Zealand, Dept Pulm & Infect Dis, Hillerod, Denmark

[10] Aarhus Univ, Natl Ctr Register Based Res, Aarhus BSS, Aarhus, Denmark

[11] Aarhus Univ, Dept Publ Hlth, DK-8000 Aarhus, Denmark

[12] Univ Plymouth, Sch Geog Earth & Environm Sci, Plymouth PL4 8AA, England

[13] Copenhagen Univ Hosp, Heart Ctr, Rigshosp, Copenhagen, Denmark

[14] Copenhagen Univ Hosp, Recurrent Pregnancy Loss Unit, Hvidovre, Denmark

[15] Rigshosp, Copenhagen, Denmark

[16] Copenhagen Univ Hosp, Dept Obstet & Gynecol, Hvidovre, Denmark

[17] Psychiat Ctr Copenhagen, Copenhagen Affect Disorder Res Ctr CADIC, Copenhagen, Denmark

[18] Aalborg Univ, Dept Hlth Sci & Technol, Aalborg, Denmark

[19] Univ Copenhagen, Novo Nord Fdn Ctr Basic Metab Res, Fac Hlth & Med Sci, Copenhagen, Denmark

[20] Univ Copenhagen, Dept Immunol & Microbiol, LEO Fdn, Skin Immunol Res Ctr, Copenhagen, Denmark

[21] Rigshosp, Danish Ctr Sleep Med, Dept Clin Neurophysiol, Copenhagen, Denmark

[22] Copenhagen Univ Hosp, Rigshosp, Dept Clin Biochem, Copenhagen, Denmark

[23] Tech Univ Denmark, Ctr Diagnost, DTU Hlth Technol, DK-2800 Lyngby, Denmark

[24] Rigshosp, Ctr Rheumatol & Spine Dis, Copenhagen Lupus & Vasculitis Clin, Copenhagen, Denmark

[25] Copenhagen Univ Hosp, Danish Headache Ctr, Rigshosp Glostrup, Glostrup, Denmark

[26] Copenhagen Univ Hosp, Danish Multiple Sclerosis Ctr, Rigshosp Glostrup, Glostrup, Denmark

[27] Zealand Univ, Dept Ophthalmol, Clin Eye Res Div, Roskilde, Denmark

[28] Aalborg Univ Hosp, Dept Clin Immunol, Aalborg, Denmark

[29] Odense Univ Hosp, Dept Clin Immunol, Odense, Denmark

[30] Statens Serum Inst, Dept Epidemiol Res, Copenhagen, Denmark

[31] Danish Canc Soc, Danish Canc Soc Res Ctr, Copenhagen, Denmark

[32] Copenhagen Univ Hosp, Dept Hematol, Copenhagen, Denmark

[33] Statens Serum Inst, Copenhagen, Denmark

[34] Zealand Univ Hosp, Dept Clin Immunol, Koge, Denmark

来源：

COMMUNICATIONS MEDICINE | 2024年 / 4卷 / 01期

关键词：

CIGARETTE-SMOKE; MARKERS; OBESITY; SEX; EXPOSURE; COHORT; WOMEN;

D O I：

10.1038/s43856-024-00474-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

BackgroundThe emerging use of biomarkers in research and tailored care introduces a need for information about the association between biomarkers and basic demographics and lifestyle factors revealing expectable concentrations in healthy individuals while considering general demographic differences.MethodsA selection of 47 biomarkers, including markers of inflammation and vascular stress, were measured in plasma samples from 9876 Danish Blood Donor Study participants. Using regression models, we examined the association between biomarkers and sex, age, Body Mass Index (BMI), and smoking.ResultsHere we show that concentrations of inflammation and vascular stress biomarkers generally increase with higher age, BMI, and smoking. Sex-specific effects are observed for multiple biomarkers.ConclusionThis study provides comprehensive information on concentrations of 47 plasma biomarkers in healthy individuals. The study emphasizes that knowledge about biomarker concentrations in healthy individuals is critical for improved understanding of disease pathology and for tailored care and decision support tools. Blood-based biomarkers are circulating molecules that can help to indicate health or disease. Biomarker levels may vary depending on demographic and lifestyle factors such as age, sex, smoking status, and body mass index. Here, we examine the effects of these demographic and lifestyle factors on levels of biomarkers related to activation of the immune system and cardiovascular stress. Measurements of 47 different proteins were performed on blood samples from nearly 10,000 healthy Danish blood donors. Measurement data were linked with questionnaire data to assess effects of lifestyle. We found that immune activation and vascular stress generally increased with age, BMI, and smoking. As these measurements are from healthy blood donors they can serve as a reference for expectable effects and inflammation levels in healthy individuals. Knowledge about the healthy state is important for understanding disease progression and optimizing care. Kjerulff et al. evaluate 47 biomarkers, including markers of inflammation and vascular stress, and their associations with demographic and lifestyle factors in healthy participants from the Danish Blood Donor study. Circulating biomarker levels varied according to sex, age, BMI and smoking status.

引用

页数：15

共 39 条

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