Prognostic Value of sST2 in Heart Failure

被引：18
|
作者：
Sciatti, Edoardo [1 ]
Merlo, Anna [2 ]
Scangiuzzi, Claudio [2 ]
Limonta, Raul [2 ]
Gori, Mauro [1 ]
D'Elia, Emilia [1 ]
Aimo, Alberto [3 ,4 ]
Vergaro, Giuseppe [3 ,4 ]
Emdin, Michele [3 ,4 ]
Senni, Michele [1 ,2 ]
机构：
[1] ASST Papa Giovanni XXIII, Cardiol Unit, I-24127 Bergamo, Italy
[2] Univ Milano Bicocca, Sch Med & Surg, I-20126 Milan, Italy
[3] Scuola Super Sant Anna, Hlth Sci Interdisciplinary Ctr, I-56127 Pisa, Italy
[4] Fdn Toscana G Monasterio, I-56124 Pisa, Italy
来源：
JOURNAL OF CLINICAL MEDICINE | 2023年 / 12卷 / 12期
关键词：
ST2; heart failure; biomarker; natriuretic peptide; prognosis; SENSITIVITY TROPONIN-T; SOLUBLE ST2; NATRIURETIC PEPTIDE; MYOCARDIAL FIBROSIS; RISK STRATIFICATION; BIOMARKERS; MORTALITY; RECEPTOR; PREDICTION; MANAGEMENT;
D O I：
10.3390/jcm12123970
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In recent years, there has been growing interest in the risk stratification for heart failure, and the use of multiple biomarkers to identify different pathophysiological processes associated with this condition. One such biomarker is soluble suppression of tumorigenicity-2 (sST2), which has shown some potential for integration into clinical practice. sST2 is produced by both cardiac fibroblasts and cardiomyocytes in response to myocardial stress. Other sources of sST2 are endothelial cells of the aorta and coronary arteries and immune cells such as T cells. Indeed, ST2 is also associated with inflammatory and immune processes. We aimed at reviewing the prognostic value of sST2 in both chronic and acute heart failure. In this setting, we also provide a flowchart about its potential use in clinical practice.
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页数：10
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