Role of mouse dendritic cell subsets in priming naive CD4 T cells

被引：4
|
作者：
Tatsumi, Naoya [1 ,2 ]
Kumamoto, Yosuke [1 ,2 ]
机构：
[1] Rutgers New Jersey Med Sch, Ctr Immun & Inflammat, Newark, NJ 07103 USA
[2] Rutgers New Jersey Med Sch, Dept Pathol Immunol & Lab Med, Newark, NJ 07103 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2023年 / 83卷
基金：
美国国家卫生研究院;
关键词：
IN-VIVO; ANTIGEN; DISTINCT; IMMUNITY; REVEALS; DIFFERENTIATION; POPULATIONS; GENERATION; INFECTION; MIGRATION;
D O I：
10.1016/j.coi.2023.102352
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Conventional dendritic cells (cDCs) are potent antigenpresenting cells that consist of developmentally, phenotypically, and functionally distinct subsets. Following immunization, each subset of cDCs acquires the antigen and spatiotemporal kinetics in the secondary lymphoid organs, often causing multiple waves of antigen presentation to CD4T cells. Here, we review the current understanding of the kinetics of antigen presentation by each cDC subset and its functional consequences in priming naive CD4T cells, and discuss its implications in the differentiation of CD4T cells.
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页数：7
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