NiFe2O4@SiO2-Cu as a novel and efficient magnetically recoverable nanocatalyst for regioselective synthesis of β-thiol-1,2,3-triazoles under benign conditions

A green, mild and eco-friendly approach for the three component one- pot regioselective synthesis of 1,2,3-triazoles from thiiranes has been introduced in the presence of NiFe2O4@SiO2-Cu as a new and recoverable nanocatalyst. First, the NiFe2O4 nanoparticles have been produced through a solid-state reaction of hydrated nickel sulfate, hydrated iron(III) nitrate, NaOH and NaCl salts, and then calcined at 700 degrees C. Next, in order to protect the ferrite particles from oxidation and aggregation, the NiFe2O4 was core-shelled using tetraethyl orthosilicate (TEOS) and converted to NiFe2O4@SiO2. Finally, the novel NiFe2O4@ SiO2-Cu nanocomposite was successfully prepared by adding copper(II) chloride solution and solid potassium borohydride. The catalyst has been characterized by FT- IR, SEM, EDX, VSM, ICP-OES, TEM and XRD techniques. The 1,3-dipolar cyclization of 1,2,3- triazoles was performed successfully in water at room temperature in high yields. The recoverability and reusability of the heterogeneous NiFe2O4@SiO2-Cu have also been investigated using VSM, SEM and FT-IR analyses. The catalyst was used four times in consecutive runs without considerable loss of activity. The presented procedure provides significant benefits such as using water as a green solvent, absence of hazardous organic solvents, high yields, benign conditions and recyclability of the magnetic catalyst.