In Vivo Gene Delivery Using Exosomes Engineered to Contain AAV Improves Transduction Efficiency and Resists Neutralizing Antibodies

被引:0
|
作者
McConnell, Russell [1 ]
Lule, Sevda [1 ]
Zi, Tong [1 ]
Jang, Su Chul [1 ]
Noyes, Aaron [1 ]
Sathy, Sriram [1 ]
机构
[1] Codiak BioSci, Cambridge, MA USA
关键词
D O I
暂无
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
461
引用
收藏
页码:237 / 238
页数:2
相关论文
共 50 条
  • [21] Erratum: Global CNS gene delivery and evasion of anti-AAV-neutralizing antibodies by intrathecal AAV administration in non-human primates
    S J Gray
    S Nagabhushan Kalburgi
    T J McCown
    R Jude Samulski
    Gene Therapy, 2013, 20 (4) : 465 - 465
  • [22] A Novel Engineered AAV2 Capsid Variant CereAAV™ for Efficient In Vivo Gene Transduction into Mouse and Marmoset Brain
    Tanaka, Y.
    Nariki, H.
    Ueda, S.
    Tanaka, R.
    Nishie, T.
    Takashima, F.
    Okamoto, S.
    Enoki, T.
    Mineno, J.
    HUMAN GENE THERAPY, 2022, 33 (23-24) : A31 - A31
  • [23] Engineered AAV8 capsid acquires heparin and AVB sepharose binding capacity but has altered in vivo transduction efficiency
    Laura P. van Lieshout
    Ashley A. Stegelmeier
    Tara N. Rindler
    John J. Lawder
    Debra L. Sorensen
    Kathy L. Frost
    Stephanie A. Booth
    James P. Bridges
    Sarah K. Wootton
    Gene Therapy, 2023, 30 : 236 - 244
  • [24] Engineered AAV8 capsid acquires heparin and AVB sepharose binding capacity but has altered in vivo transduction efficiency
    van Lieshout, Laura P.
    Stegelmeier, Ashley A.
    Rindler, Tara N.
    Lawder, John J.
    Sorensen, Debra L.
    Frost, Kathy L.
    Booth, Stephanie A.
    Bridges, James P.
    Wootton, Sarah K.
    GENE THERAPY, 2023, 30 (3-4) : 236 - 244
  • [25] Microbubble ultrasound improves the efficiency of gene transduction in skeletal muscle in vivo with reduced tissue damage
    Lu, QL
    Liang, HD
    Partridge, T
    Blomley, MJK
    GENE THERAPY, 2003, 10 (05) : 396 - 405
  • [26] Microbubble ultrasound improves the efficiency of gene transduction in skeletal muscle in vivo with reduced tissue damage
    Q L Lu
    H-D Liang
    T Partridge
    M J K Blomley
    Gene Therapy, 2003, 10 : 396 - 405
  • [27] Bioengineering of AAV2 Capsid at Specific Serine, Threonine, or Lysine Residues Improves Its Transduction Efficiency in Vitro and in Vivo
    Gabriel, Nishanth
    Hareendran, Sangeetha
    Sen, Dwaipayan
    Gadkari, Rupali A.
    Sudha, Govindarajan
    Selot, Ruchita
    Hussain, Mansoor
    Dhaksnamoorthy, Ramya
    Samuel, Rekha
    Srinivasan, Narayanaswamy
    Srivastava, Alok
    Jayandharan, Giridhara R.
    HUMAN GENE THERAPY METHODS, 2013, 24 (02) : 80 - U117
  • [28] Neutralizing antibody abrogation of TGF-beta activity during retroviral transduction improves gene transfer efficiency.
    Yu, JM
    Soma, T
    Dunbar, CE
    BLOOD, 1995, 86 (10) : 934 - 934
  • [29] Engineered Protein M Analogs Enhance the Ability to Suppress Vector Neutralizing Antibodies and Generate a Window for Successful Gene Delivery
    Askew, Charles
    Thieker, David
    Chai, Zheng
    Kuhlman, Brian
    Li, Chengwen
    MOLECULAR THERAPY, 2021, 29 (04) : 91 - 91
  • [30] The prevalence of neutralizing antibodies against AAV serotype 1 in healthy subjects in China: Implications for gene therapy and vaccines using AAV1 vector
    Liu, Qiang
    Huang, Weijin
    Zhao, Chenyan
    Zhang, Li
    Meng, Shufang
    Gao, Dongying
    Wang, Youchun
    JOURNAL OF MEDICAL VIROLOGY, 2013, 85 (09) : 1550 - 1556