Predicting which patients with cirrhosis will develop overt hepatic encephalopathy: Beyond psychometric testing

被引:3
|
作者
Saleh, Zachary M. [1 ]
Tapper, Elliot B. [2 ]
机构
[1] Univ Michigan Hlth Syst, Dept Internal Med, Ann Arbor, MI 48109 USA
[2] Univ Michigan Hlth Syst, Div Gastroenterol, 3912 Taubman,SPC 5362,1500 E Med Ctr Dr, Ann Arbor, MI 48109 USA
基金
美国国家卫生研究院;
关键词
Ammonia; Portal hypertension; Inflammation; Liver disease; DIAGNOSIS; ENCEPHALAPP; VALIDATION; RISK;
D O I
10.1007/s11011-022-01112-3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
It remains challenging to identify covert hepatic encephalopathy and predict progression to overt hepatic encephalopathy. Psychometric testing is a widely used diagnostic modality, but it is often inaccurate and difficult to implement in diverse populations, making it a less than ideal assessment. Alternatively, by using easily accessible data from the electronic health record, simple clinical assessment tools, and patient-reported outcomes, we may be better able to predict hepatic encephalopathy across multiple populations. Furthermore, incorporation of patient-reported outcomes into our diagnostic toolset not only aids detection of covert hepatic encephalopathy and prediction of overt hepatic encephalopathy, but also allows us to target therapies and track their impact. Herein, we outline a potential algorithm based on these easily integrated tools to promote patient risk-stratification and early therapeutic intervention.
引用
收藏
页码:1701 / 1706
页数:6
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