The expanding role of BAP1 in clear cell renal cell carcinoma

被引：12
|
作者：
Kapur, Payal [1 ,2 ,3 ,6 ]
Rajaram, Satwik [1 ,4 ]
Brugarolas, James [3 ,5 ]
机构：
[1] Univ Texas Southwestern Med Ctr, Dept Pathol, Dallas, TX 75390 USA
[2] Univ Texas Southwestern Med Ctr, Dept Urol, Dallas, TX 75390 USA
[3] Simmons Comprehens Canc Ctr, Kidney Canc Program, Dallas, TX 75390 USA
[4] Univ Texas Southwestern Med Ctr, Lyda Hill Dept Bioinformat, Dallas, TX 75390 USA
[5] Univ Texas Southwestern Med Ctr, Dept Internal Med Hematol Oncol, Dallas, TX 75390 USA
[6] Univ Texas Southwestern Med Ctr, Dept Pathol, Kidney Canc Program, 5323 Harry Hines Blvd, Dallas, TX 75390 USA
来源：
HUMAN PATHOLOGY | 2023年 / 133卷
关键词：
BAP1; ccRCC; RCC; PBRM1; TUMOR-SUPPRESSOR; BRCA1-ASSOCIATED PROTEIN-1; MUTATIONS PREDISPOSE; PBRM1; OUTCOMES; SETD2; VHL; INACTIVATION; ACTIVATION; EXPRESSION;
D O I：
10.1016/j.humpath.2022.07.022
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Mutations drive renal cell carcinoma biology and tumor growth. The BRCA1-associated protein-1 (BAP1) gene is frequently mutated in clear cell renal cell carcinoma (ccRCC) and has emerged as a prognostic and putative predictive biomarker. In this review, we discuss the role of BAP1 as a signature event of a subtype of ccRCC marked by aggressiveness, inflammation, and possibly a heightened response to immunotherapy. (c) 2022 Elsevier Inc. All rights reserved.
引用
收藏
页码：22 / 31
页数：10
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