Chemoselective Strain Release of Bicyclo[1.1.1]pent-1-yl Alcohols

被引：0
|
作者：
Ma, Yue [1 ]
Ai, Yinan [1 ]
Yu, Songjie [1 ,2 ]
机构：
[1] Dalian Univ Technol, Zhang Dayu Sch Chem, Dalian 116024, Peoples R China
[2] Shandong Univ, Inst Mol Sci & Engn, Inst Frontier & Interdisciplinary Sci, Qingdao 266237, Peoples R China
来源：
SYNLETT | 2023年 / 34卷 / 04期
关键词：
bicyclopentyl alcohols; strain release; C-C bond cleavage; chemoselectivity; cyclobutanones; enones; C-C BOND; CYCLOBUTANOLS REGIOSPECIFIC SYNTHESIS; TERT-CYCLOBUTANOLS; CLEAVAGE; CYCLOPROPANOLS; BENZOCYCLOBUTENOLS; CYCLOALKANOLS; ACTIVATION; GENERATION; AMINATION;
D O I：
10.1055/a-1992-6707
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The chemoselective C-C bond cleavage of bicyclo[1.1.1]pent-1-yl alcohols (BCP-OHs) was examined. Highly ring strained BCP-OHs were found to be particularly reactive, delivering cyclobutanone derivatives through a base-mediated single C-C bond cleavage or ?,?-unsaturated ketones by palladium-catalyzed dual C-C bond cleavage.
引用
收藏
页码：359 / 363
页数：5
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