Chemoselective Strain Release of Bicyclo[1.1.1]pent-1-yl Alcohols

被引：0

作者：

Ma, Yue ^{[1
]}

Ai, Yinan ^{[1
]}

Yu, Songjie ^{[1
,2
]}

机构：

[1] Dalian Univ Technol, Zhang Dayu Sch Chem, Dalian 116024, Peoples R China

[2] Shandong Univ, Inst Mol Sci & Engn, Inst Frontier & Interdisciplinary Sci, Qingdao 266237, Peoples R China

来源：

SYNLETT | 2023年 / 34卷 / 04期

关键词：

bicyclopentyl alcohols; strain release; C-C bond cleavage; chemoselectivity; cyclobutanones; enones; C-C BOND; CYCLOBUTANOLS REGIOSPECIFIC SYNTHESIS; TERT-CYCLOBUTANOLS; CLEAVAGE; CYCLOPROPANOLS; BENZOCYCLOBUTENOLS; CYCLOALKANOLS; ACTIVATION; GENERATION; AMINATION;

D O I：

10.1055/a-1992-6707

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The chemoselective C-C bond cleavage of bicyclo[1.1.1]pent-1-yl alcohols (BCP-OHs) was examined. Highly ring strained BCP-OHs were found to be particularly reactive, delivering cyclobutanone derivatives through a base-mediated single C-C bond cleavage or ?,?-unsaturated ketones by palladium-catalyzed dual C-C bond cleavage.

引用

页码：359 / 363

页数：5

共 24 条

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