Track: Machine Learning in Protein Science A General Method to Predict the Effect of Single Amino Acid Substitutions on Enzyme Catalytic Activity

被引：0

作者：

Lin, Yu-Hsiu ^{[1
]}

Huang, Cheng Lai ^{[1
]}

Ho, Christina ^{[1
]}

Shatsky, Max ^{[1
]}

Kirsch, Jack ^{[1
]}

机构：

[1] Univ Texas Hlth San Antonio, San Antonio, TX USA

来源：

PROTEIN SCIENCE | 2023年 / 32卷

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

ABS270

引用

页数：1

共 31 条

[21] The effect of amino-acid substitutions I112P, D147E and K152N in CYP11B2 on the catalytic activities of the enzyme
Bechtel, S
Belkina, N
Bernhardt, R
EUROPEAN JOURNAL OF BIOCHEMISTRY, 2002, 269 (04): : 1118 - 1127
[22] AMINO-ACID SUBSTITUTIONS FAR FROM THE ACTIVE-SITE OF BACTERIOPHAGE-T4 LYSOZYME REDUCE CATALYTIC ACTIVITY AND SUGGEST THAT THE C-TERMINAL LOBE OF THE ENZYME PARTICIPATES IN SUBSTRATE BINDING
GRUTTER, MG
MATTHEWS, BW
JOURNAL OF MOLECULAR BIOLOGY, 1982, 154 (03) : 525 - 535
[23] GENETIC-STUDIES ON THE BETA-SUBUNIT OF ESCHERICHIA-COLI RNA-POLYMERASE .1. THE EFFECT OF KNOWN, SINGLE AMINO-ACID SUBSTITUTIONS IN AN ESSENTIAL PROTEIN
NENE, V
GLASS, RE
MOLECULAR & GENERAL GENETICS, 1982, 188 (03): : 399 - 404
[24] SELECTIVE SUPPRESSION OF THE CATALYTIC ACTIVITY OF CDNA-EXPRESSED CYTOCHROME-P4502B1 TOWARD POLYCYCLIC-HYDROCARBONS IN THE MICROSOMAL MEMBRANE - MODIFICATION OF THIS EFFECT BY SPECIFIC AMINO-ACID SUBSTITUTIONS
CHRISTOU, M
MITCHELL, MJ
AOYAMA, T
GELBOIN, HV
GONZALEZ, FJ
JEFCOATE, CR
BIOCHEMISTRY, 1992, 31 (10) : 2835 - 2841
[25] Effect of high-temperature, short-time cooking conditions on in vitro protein digestibility, enzyme inhibitor activity and amino acid profile of selected legume grains
Adeleye, Oluwafunmilayo O.
Awodiran, Seun T.
Ajayi, Atinuke O.
Ogunmoyela, Toluwalope F.
HELIYON, 2020, 6 (11)
[26] Effect of K223E and K226E amino acid substitutions in PsbO protein of photosystem 2 on stability and functional activity of the water-oxidizing complex in Chlamydomonas reinhardtii
A. V. Pigolev
D. S. Timoshevsky
V. V. Klimov
Biochemistry (Moscow), 2012, 77 : 71 - 77
[27] Effect of K223E and K226E amino acid substitutions in PsbO protein of photosystem 2 on stability and functional activity of the water-oxidizing complex in Chlamydomonas reinhardtii
Pigolev, A. V.
Timoshevsky, D. S.
Klimov, V. V.
BIOCHEMISTRY-MOSCOW, 2012, 77 (01) : 71 - 77
[28] SEQUENCE REQUIREMENTS FOR CYTOCHROME-P-450IID1 CATALYTIC ACTIVITY - A SINGLE AMINO-ACID CHANGE (ILE380 PHE) SPECIFICALLY DECREASES VMAX OF THE ENZYME FOR BUFURALOL BUT NOT DEBRISOQUINE HYDROXYLATION
MATSUNAGA, E
ZEUGIN, T
ZANGER, UM
AOYAMA, T
MEYER, UA
GONZALEZ, FJ
JOURNAL OF BIOLOGICAL CHEMISTRY, 1990, 265 (28) : 17197 - 17201
[29] regulation of G protein activation and effector modulation by fusion proteins between the human 5-hydroxytryptamine1A receptor and the α subunit of Gi1α:: Differences in receptor-constitutive activity imparted by single amino acid substitutions in Gi1α
Kellett, E
Carr, IC
Milligan, G
MOLECULAR PHARMACOLOGY, 1999, 56 (04) : 684 - 692
[30] Effect of a single amino acid substitution in the NLS domain of Tomato yellow leaf curl virus-Israel (TYLCV-IL) capsid protein (CP) on its activity and on the virus life cycle
Yaakov, Noga
Levy, Yael
Belausov, Eduard
Gaba, Victor
Lapidot, Moshe
Gafni, Yedidya
VIRUS RESEARCH, 2011, 158 (1-2) : 8 - 11

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