EXPRESSION OF BASIC FIBROBLAST GROWTH FACTOR,TRANSFORMING GROWTH FACTOR β1 AND THEIRRECEPTORS IN OSTEOSARCOMA AND ITSRELATIONSHIP TO ANGIOGENESIS

Objective: To investigate the expression ofangiogenic factors, basic fibroblast growth factor (bFGF)and transforming growth factor (TGF)-β1 inosteosarcoma, its association with neovascularizationand prognosis. Methods: The expression of bFGF, TGFβ1 and their receptors, as well as intratumoralmicrovcssel count (MVD) were studied in 80osteosarcomas by immunohistochemical staining andmorphometry. The relationship between the angiogenicfactors expression and prognosis was evaluated by amultivariate analysis using Cox proportion hazardmodel. Results: Among 80 cases of osteosarcoma, 46cases were positive for bFGFlbFGFr (57.5%), and 31cases for TGF-β1/ TGF-β (RI)(38.8%) respectively. TheMVD and bFGF, TGF-β1, were important indicators topredict the prognosis of patients with osteosarconla bythe Cox proportion hazard model analysis. Conclusioll:The angiogenic factors bFGF and TGF-β1 are involvedin the angiogenesis of osteosarcoma, and theangiogenesis inf’luences the prognosis. Also they may beuseful in the evaluation of the prognosis of patients withosteosarcoma.