Collagen type XVI expression is modulated by basic fibroblast growth factor and transforming growth factor-β

被引：22
|
作者：
Grässel, S
Tan, EML
Timpl, R
Chu, ML
机构：
[1] Thomas Jefferson Univ, Dept Dermatol & Cutaneous Biol, Philadelphia, PA 19107 USA
[2] Thomas Jefferson Univ, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USA
[3] Max Planck Inst, Dept Prot Chem, Martinsried, Germany
[4] Thomas Jefferson Univ, Dept Biochem & Mol Pharmacol, Philadelphia, PA 19107 USA
来源：
FEBS LETTERS | 1998年 / 436卷 / 02期
关键词：
transforming growth factor-beta; basic fibroblast growth factor; collagen XVI; arterial smooth muscle cell; dermal fibroblast;
D O I：
10.1016/S0014-5793(98)01122-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We investigated the effects of bFGF and TGF-beta on the expression of type XVI collagen, a member of the fibril associated collagen family, in human dermal fibroblasts and arterial smooth muscle cells. We found that bFGF decreased the alpha 1(XVI) collagen mRNA to 18-24% of the controls, while TGF-beta increased the mRNA to 150-360%, Immunoprecipitation of metabolically labeled cells revealed corresponding, but less pronounced, changes at the protein levels. The results suggested that type XVI collagen expression is regulated by bFGF and TGF-beta in a manner similar to their regulation of the major type I fibrillar collagen produced bg these cells. (C) 1998 Federation of European Biochemical Societies.
引用
收藏
页码：197 / 201
页数：5
相关论文
共 50 条
  • [1] Increased expression of transforming growth factor-β1, acidic fibroblast growth factor, and basic fibroblast growth factor in fetal versus adult fibroblast cell lines
    Lee, NJ
    Wang, SJ
    Durairaj, KK
    Srivatsan, ES
    Wang, MB
    [J]. LARYNGOSCOPE, 2000, 110 (04): : 616 - 619
  • [2] The effects of basic fibroblast growth factor, transforming growth factor-α, and transforming growth factor-β on mesenchymal cells in the rabbit phallus:: An in-vitro study
    Katsuki, M
    Furukawa, H
    Doi, Y
    Hamasaki, K
    Nishino, T
    [J]. ARCHIVES OF HISTOLOGY AND CYTOLOGY, 1997, 60 (05) : 463 - 475
  • [3] Patterns of epidermal growth factor receptor, basic fibroblast growth factor and transforming growth factor-β3 expression in skin with chronic venous insufficiency
    Peschen, M
    Grenz, H
    Grothe, C
    Schopf, E
    Vanscheidt, W
    [J]. EUROPEAN JOURNAL OF DERMATOLOGY, 1998, 8 (05) : 334 - 338
  • [4] Effect of γδ T cell supernatant on human skin fibroblast proliferation and collagen production - Possible role of transforming growth factor-β and basic fibroblast growth factor
    Ohtsuka, Tsutomu
    [J]. INTERNATIONAL JOURNAL OF DERMATOLOGY, 2008, 47 (11) : 1135 - 1140
  • [5] Circadian variations of transforming growth factor-β2 and basic fibroblast growth factor in the rabbit aqueous humor
    Liu, JHK
    [J]. CURRENT EYE RESEARCH, 2002, 24 (01) : 75 - 80
  • [6] Effects of 530 nm monochromatic light on basic fibroblast growth factor and transforming growth factor-β1 expression in Muller cells
    Fu, Xin-Yi
    Zhang, Xiao-Feng
    Xia, Wei
    Zhong, Lei
    Wang, Ying-Ming
    Sun, Zheng-Tai
    Xia, Jing
    [J]. INTERNATIONAL JOURNAL OF OPHTHALMOLOGY, 2015, 8 (05) : 904 - 909
  • [7] Expression of transforming growth factor-β type I receptor and transforming growth factor-β type II receptor in rat retina
    Shen, Wei
    Liu, Lin
    [J]. INTERNATIONAL JOURNAL OF OPHTHALMOLOGY, 2009, 2 (03) : 204 - 206
  • [8] BASIC FIBROBLAST GROWTH FACTOR SUPPRESSES TRANSFORMING GROWTH FACTOR-β1-MEDIATED HUMAN CARDIAC FIBROBLAST DIFFERENTIATION INTO MYOFIBROBLASTS
    Ngu, J. M.
    Teng, G.
    Upon, B. D.
    Mewhort, H. E.
    Seneviratne, C. K.
    Fedak, P. W.
    [J]. CANADIAN JOURNAL OF CARDIOLOGY, 2013, 29 (10) : S362 - S363
  • [9] Overaccumulation of transforming growth factor-β1 and basic fibroblast growth factor in lens epithelial cells of congenital cataract
    Xiao, Ying
    Zhao, Bojun
    Gao, Zhijuan
    Pan, Qingmin
    [J]. CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE, 2009, 44 (02): : 189 - 192
  • [10] Platelet-derived growth factor, basic fibroblast growth factor, and interferon γ increase type IV collagen production in human fetal mesangial cells via a transforming growth factor-β-dependent mechanism
    Yamabe, H
    Osawa, H
    Kaizuka, M
    Tsunoda, S
    Shirato, K
    Tateyama, F
    Okumura, K
    [J]. NEPHROLOGY DIALYSIS TRANSPLANTATION, 2000, 15 (06) : 872 - 876
12345