NUCLEAR MORPHOMETRY AND ITS PROGNOSTIC SIGNIFICANCE IN LARYNGEAL SQUAMOUS CELL CARCINOMAS

The five parameters including nuclear area（NA）,nuclear perimeter（NP）,nuclear diameter（ND）,axisratio and nuclear roundness were evaluated withMIAS200 Image Analysis System（SichuanUniversity,Chengdu）in 45 patients with laryngealprimary squamous cell carcinoma,which were con-firmed pathologically and operated on from January1977 to October 1987.The results showed that NA,NP and ND are important prognostic indicators.Thesurvival rate in patients with large nuclei（NA≥73μm,NP≥32.5μm,ND≥12μm）was significantly lowerthan that in those with small nuclei（NA<73μm,NP<32.5μm,ND<12μm）(P<0.0025).These find-ings strongly suggest that patients with laryngealsquamous cell carcinoma with large nuclei should betreated more aggressively.