Influence of the number of high-risk cytogenetic abnormalities on the clinical characteristics and prognosis in 360 patients with newly diagnosed multiple myeloma

Objective To investigate the influence of the number of high-risk cytogenetic abnormalities (HRCA)on the clinical characteristics and prognosis of patients with newly diagnosed multiple myeloma (MM).Methods A total of 360 patients with newly diagnosed MM admitted to Jiangsu Province Hospital between November 2013 and September 2020 were included in this study. Cytoplasmic light chain immunofluorescence with fluorescence in situ hybridization (cIg-FISH) was used to detect HRCA. Cytogenetic abnormalities were combined with clinical characteristics and outcomes for further analysis. Results Among the 360 patients,120patients (33.3%) didn’t present with HRCAs,and 175(48.6%),61 (16.9%),and four (1.1%) patients had one, two, and three HRCA (s), respectively.