Relationship between baseline monocyte to high-density lipoprotein cholesterol ratio and acute heart failure in postmenopausal women with acute coronary syndromes

Monocyte to high-density lipoprotein cholesterol ratio(MHR) becomes a novel cardiovascular prognostic predictor. The retrospective study was performed to investigate the relationship between MHR and acute heart failure(AHF) in postmenopausal women with acute coronary syndromes(ACS). Methods A cohort of 127 postmenopausal women diagnosed with ACS were enrolled. They underwent coronary angiography in Shantou Central Hospital(Shantou, China) from December 2014 and July 2016. The patients were assigned to two groups based on the admission MHR: low MHR group(MHR ≤0.3677, n=51) and high MHR group(MHR >0.3677, n=76). The relationship between MHR and AHF was assessed by logistic regression analysis. Results Left ventricular ejection fraction of the low MHR group(64.2%±8.8%) was higher than that of the high MHR group(57.6%±12.9%)(P=0.002). Fractional shortening of the low MHR group(35.4%±6.4%) was higher than that of the high MHR group(30.6%±8.9%)(P=0.001). Hospitalization days of high MHR group(11.4±6.6 days)was longer than that of low MHR group(8.4±3.5 days)(P=0.006). Incidence of AHF(21%) in the high MHR group was higher than that in the low MHR group(4%)(P=0.008). MHR(OR: 25.701, 95% CI: 3.099-213.143,P=0.003) could be an independent predictor for AHF in postmenopausal women with acute coronary syndromes.Conclusions The incidence of AHF in high baseline MHR group was higher than that in low baseline MHR group. This study demonstrated that high MHR level was a risk factor for AHF in postmenopausal women with ACS. [S Chin J Cardiol 2021;22(3):145-153]