The Relationship between Coronary Thrombus Burden and Monocyte to High-Density Lipoprotein Cholesterol Ratio in Patients with Acute Non-ST Elevation Myocardial Infarction

Introduction: Non-ST-segment elevation myocardial infarction (NSTEMI) is a condition that constitutes a large part of acute coronary syndromes and has a high mortality rate with diffuse vascular disease. The aim of this study was to examine the association between monocyte to high-density lipoprotein cholesterol ratio (MHR) and thrombus burden, which is indicative of inflammation and cardiovascular endpoints in patients with NSTEMI. Methods: We retrospectively evaluated 205 consecutive patients who underwent coronary angiography for NSTEMI in our tertiary center. Complete blood count and biochemical analysis were performed using blood samples. Angiographic thrombus burden was classified as previously described by thrombolysis in the myocardial infarction (TIMI) study group. Results: Patients with high thrombus burden had higher monocyte count, MHR and platelet count compared to the group with low thrombus burden. TIMI and Syntax scores were also higher in the high thrombus burden group. Multiple logistic regression analysis revealed that TIMI and MHR values were independently related to high thrombus burden. [Odds ratio (OR): 1.678 (1.120-2.515) p=0.012) and OR: 1.432 (1.102-1.861), p=0.007) respectively.] Conclusion: In our study, we found that MHR was closely related to thrombus burden in patients with NSTEMI. With further studies, MHR may be a helpful parameter for risk scoring informing long-term morbidity and mortality.