Organocatalytic cascade 1,6-conjugate addition/annulation/tautomerization of functionalized para-quinone methides: Access to chiral 2-amino-4-aryl-4H-chromenes

被引：2

作者：

Cong Duan ^{[1
]}

Ling Ye ^{[2
]}

Wenqin Xu ^{[1
]}

Xinying Li ^{[1
]}

Feng Chen ^{[1
]}

Zhigang Zhao ^{[1
]}

Xuefeng Li ^{[1
]}

机构：

[1] College of Chemistry and Environment Protection Engineering, Southwest Minzu University

[2] Faculty of Geosciences and Environmental Engineering, Southwest Jiaotong University

来源：

Chinese Chemical Letters | 2018年 / 29卷 / 08期

基金：

中央高校基本科研业务费专项资金资助; 中国国家自然科学基金;

关键词：

para-Quinone methides; 2-Amino-4-aryl-4H-chromene; Domino reaction; 1,6-Conjugated addition; Enantioselective;

D O I：

暂无

中图分类号：

O625.6 [芳香族含氮化合物];

学科分类号：

070303 ; 081704 ;

摘要：

A novel organocatalytic cascade process initiated by 1,6-conjugated addition has been successfully developed. A range of pharmaceutically active 2-amino-4-aryl-4H-chromenes were readily obtained in high yields(88%-99%) and excellent enantiopurities(86%-99% ee). The functionalized para-Quinone methides(p-OMs) could be facilely obtained.

引用

页码：1273 / 1276

页数：4

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