Influencing factors and strategies of enhancing nanoparticles into tumors in vivo

被引：4
|
作者：
Mingming Zhang [1 ]
Shan Gao [1 ]
Dongjuan Yang [1 ]
Yan Fang [1 ]
Xiaojie Lin [1 ]
Xuechao Jin [1 ]
Yuli Liu [1 ]
Xiu Liu [1 ]
Kexin Su [1 ]
Kai Shi [1 ]
机构：
[1] Department of Pharmaceutics,School of Pharmacy,Shenyang Pharmaceutical University
来源：
Acta Pharmaceutica Sinica B | 2021年 / 11卷 / 08期
基金：
中国国家自然科学基金;
关键词：
D O I：
暂无
中图分类号：
R730.2 [肿瘤病理学、病因学];
学科分类号：
100214 ;
摘要：
The administration of nanoparticles(NPs) first faces the challenges of evading renal filtration and clearance of reticuloendothelial system(RES). After that, NPs infiltrate through the expanded endothelial space and penetrated the dense stroma of tumor microenvironment to tumor cells. As long as possible to prolong the time of NPs remaining in tumor tissue, NPs release active agent and induce pharmacological action. This review provides a comprehensive summary of the physical and chemical properties of NPs and the influence of various biological factors in tumor microenvironment, and discusses how to improve the final efficacy through adjusting the characteristics and structure of NPs. Perspectives and future directions are also provided.
引用
收藏
页码：2265 / 2285
页数：21
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