Aza-BODIPY based probe for photoacoustic imaging of ONOO~- in vivo

被引：0
|
作者：
Danghui Ma [1 ]
Shumin Hou [1 ]
Chaeeon Bae [2 ]
Thanh Chung Pham [2 ]
Songyi Lee [3 ,2 ]
Xin Zhou [1 ,4 ]
机构：
[1] Department of Chemistry, College of Chemistry and Chemical Engineering
[2] Industry 4.0 Convergence Bionics Engineering, Pukyong National University
[3] Department of Chemistry, Pukyong National University
[4] Qingdao Cancer Institute, Qingdao University
来源：
Chinese Chemical Letters | 2021年 / 32卷 / 12期
基金：
新加坡国家研究基金会; 中国博士后科学基金; 中国国家自然科学基金;
关键词：
D O I：
暂无
中图分类号：
R313 [医用化学]; TP212.2 [化学传感器];
学科分类号：
080202 ; 1001 ;
摘要：
The effective detecting ONOO~-variations in vivo is of great importance to well understand the complex pathophysiological processes. We reported here a photoacoustic(PA) probe AZB-1 for imaging ONOO~-in vivo. AZB-1 showed an originally strong photoacoustic signal at 660 nm. And its PA signal can be turned off by shutting the ICT effect caused by the conjugated electron withdrawing group at 2-position of the aza-BODIPY core. Moreover, the probe was successfully employed to imaging ONOO~-variations in inflammatory mice models. Wisely utilized this strategy may serve as powerful platforms for the preparation of novel PA chemosensors.
引用
收藏
页码：3886 / 3889
页数：4
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