Application of microfluidic technologies on COVID-19 diagnosis and drug discovery

被引：0
|
作者：
Zhun Lin [1 ]
Zhengyu Zou [2 ]
Zhe Pu [1 ]
Minhao Wu [2 ]
Yuanqing Zhang [1 ]
机构：
[1] School of Pharmaceutical Sciences, Sun Yat-sen University
[2] Zhongshan School of Medicine, Sun Yat-sen University
来源：
Acta Pharmaceutica Sinica B | 2023年 / 07期
基金：
中国国家自然科学基金;
关键词：
D O I：
暂无
中图分类号：
R563.1 [肺炎]; TQ460.1 [基础理论];
学科分类号：
1002 ; 100201 ; 1007 ;
摘要：
The ongoing coronavirus disease 2019(COVID-19) pandemic has boosted the development of antiviral research. Microfluidic technologies offer powerful platforms for diagnosis and drug discovery for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) diagnosis and drug discovery. In this review, we introduce the structure of SARS-CoV-2 and the basic knowledge of microfluidic design. We discuss the application of microfluidic devices in SARS-CoV-2 diagnosis based on detecting viral nucleic acid, antibodies, and antigens. We highlight the contribution of lab-on-a-chip to manufacturing point-ofcare equipment of accurate, sensitive, low-cost, and user-friendly virus-detection devices. We then investigate the efforts in organ-on-a-chip and lipid nanoparticles(LNPs) synthesizing chips in antiviral drug screening and mRNA vaccine preparation. Microfluidic technologies contribute to the ongoing SARSCoV-2 research efforts and provide tools for future viral outbreaks.
引用
收藏
页码：2877 / 2896
页数：20
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