All-transRetinoic Acid Regulates Th1/Th2 Balance in CD4+T cells When GATA-3 is Deficient

被引：0

作者：

ZHU Yan Feng ^{[1
]}

HU Jia Zhe ^{[2
]}

ZHAO Pin Nan ^{[3
]}

LIU Lin Xi ^{[1
]}

and LI Yun ^{[1
]}

机构：

[1] Department of Nutrition and Food Hygiene, West China School of Public Health, Sichuan University

来源：

BiomedicalandEnvironmentalSciences | 2013年 / 26卷 / 09期

基金：

中国国家自然科学基金;

关键词：

GATA; cell; Th; All-transRetinoic Acid Regulates Th1/Th2 Balance in CD4+T cells When GATA-3 is Deficient; CD;

D O I：

暂无

中图分类号：

R392.1 [免疫生物学];

学科分类号：

100102 ;

摘要：

The essential effect of vitamin A on immune function occurs through various mechanisms including direct effect on Th1-Th2 balance modulation.However,it is unclear whether or not vitamin A can regulate Th1-Th2 balance under a strong Th1-polarizing condition.Therefore,the purpose of our study was to examine the effect of vitamin A metabolite all-trans retinoic acid(ATRA)on Th1-Th2 differentiation in CD4+T cells under GATA-3 deficiency,which can induce Th1-polarizing condition.In the present study,GATA-3 deficiency T cells were induced by siRNA and checked by

引用

页码：774 / 777

页数：4

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